Title:
DISUBSTITUTED ADAMANTYL DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PHARMACEUTICAL COMPOSITION FOR SUPPRESSING CANCER GROWTH COMPRISING SAME AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2021/149900
Kind Code:
A1
Abstract:
The present invention relates to: a disubstituted adamantyl derivative or a pharmaceutically acceptable salt thereof, and an anticancer pharmaceutical composition and a kit containing same as an active ingredient. The disubstituted adamantyl derivative according to the present invention suppresses the growth of cancer cells by targeting mitochondria ETC complex I and damaging the metabolism of cancer cells, and thus can be useful as an anticancer pharmaceutical composition that is a powerful therapeutic agent for cancer dependent on oxidative phosphorylation for producing ATP.
More Like This:
| JPS62198634 | BENZALDEHYDE DIALKYLACETALS |
| JPH11263770 | NEW KETONE DERIVATIVE AND ITS USE |
| JP2012532184 | Alkenone manufacturing method |
Inventors:
LEE KYEONG (KR)
WON MI SUN (KR)
BAN HYUN-SEUNG (KR)
KIM MIN KYOUNG (KR)
KIM BO-KYUNG (KR)
WON MI SUN (KR)
BAN HYUN-SEUNG (KR)
KIM MIN KYOUNG (KR)
KIM BO-KYUNG (KR)
Application Number:
PCT/KR2020/016110
Publication Date:
July 29, 2021
Filing Date:
November 16, 2020
Export Citation:
Assignee:
UNIV DONGGUK IND ACAD COOP (KR)
KOREA RES INST BIOSCIENCE & BIOTECHNOLOGY (KR)
KOREA RES INST BIOSCIENCE & BIOTECHNOLOGY (KR)
International Classes:
C07C49/175; A61K31/472; A61P35/00; C07C233/07; C07D401/12
Foreign References:
| KR20110012127A | 2011-02-09 | |||
| KR20140072309A | 2014-06-13 | |||
| KR20130074298A | 2013-07-04 | |||
| KR20200009445A | 2020-01-30 | |||
| KR20120041071A | 2012-04-30 |
Other References:
MIN, K.H. ; XIA, Y. ; KIM, E.K. ; JIN, Y. ; KAUR, N. ; KIM, E.S. ; KIM, D.K. ; JUNG, H.Y. ; CHOI, Y. ; PARK, M.K. ; MIN, Y.K. ; LE: "A novel class of highly potent multidrug resistance reversal agents: Disubstituted adamantyl derivatives", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 19, no. 18, 15 September 2009 (2009-09-15), AMSTERDAM, NL, pages 5376 - 5379, XP026501164, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2009.07.127
GADHE CHANGDEV G., MADHAVAN THIRUMURTHY, KOTHANDAN GUGAN, LEE TAE-BUM, LEE KYEONG, CHO SEUNG-JOO: "Various Partial Charge Schemes on 3D-QSAR Models for P-gp Inhibiting Adamantyl Derivatives", BULLETIN OF THE KOREAN CHEMICAL SOCIETY, KOREAN CHEMICAL SOCIETY, KR, vol. 32, no. 5, 20 May 2011 (2011-05-20), KR, pages 1604 - 1612, XP055830984, ISSN: 0253-2964, DOI: 10.5012/bkcs.2011.32.5.1604
NAIK, R. ET AL.: "Synthesis and Structure-Activity Relationship of (E)Phenoxyacrylic Amide Derivatives as Hypoxia-Inducible Factor (HIF) la Inhibitors", J. MED. CHEM., vol. 55, 2012, pages 10564 - 1057
CHOU, T. C: "Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies", PHARMACOL. REV, vol. 58, 2006, pages 621 - 681, XP055151376, DOI: 10.1124/pr.58.3.10
NAIK, R. ET AL.: "Synthesis and Structure-Activity Relationship of (E)Phenoxyacrylic Amide Derivatives as Hypoxia-Inducible Factor (HIF) 1α Inhibitors", J. MED. CHEM., vol. 55, 2012, pages 10564 - 1057
CHOU, T. C.: "Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies", PHARMACOL. REV., vol. 58, 2006, pages 621 - 681, XP055151376, DOI: 10.1124/pr.58.3.10
HUANG, D.: "HIF-1-mediated suppression of acyl-CoA dehydrogenases and fatty acid oxidation is critical for cancer progression", CELL REP, vol. 8, 2014, pages 1930 - 1942
See also references of EP 4098647A4
GADHE CHANGDEV G., MADHAVAN THIRUMURTHY, KOTHANDAN GUGAN, LEE TAE-BUM, LEE KYEONG, CHO SEUNG-JOO: "Various Partial Charge Schemes on 3D-QSAR Models for P-gp Inhibiting Adamantyl Derivatives", BULLETIN OF THE KOREAN CHEMICAL SOCIETY, KOREAN CHEMICAL SOCIETY, KR, vol. 32, no. 5, 20 May 2011 (2011-05-20), KR, pages 1604 - 1612, XP055830984, ISSN: 0253-2964, DOI: 10.5012/bkcs.2011.32.5.1604
NAIK, R. ET AL.: "Synthesis and Structure-Activity Relationship of (E)Phenoxyacrylic Amide Derivatives as Hypoxia-Inducible Factor (HIF) la Inhibitors", J. MED. CHEM., vol. 55, 2012, pages 10564 - 1057
CHOU, T. C: "Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies", PHARMACOL. REV, vol. 58, 2006, pages 621 - 681, XP055151376, DOI: 10.1124/pr.58.3.10
NAIK, R. ET AL.: "Synthesis and Structure-Activity Relationship of (E)Phenoxyacrylic Amide Derivatives as Hypoxia-Inducible Factor (HIF) 1α Inhibitors", J. MED. CHEM., vol. 55, 2012, pages 10564 - 1057
CHOU, T. C.: "Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies", PHARMACOL. REV., vol. 58, 2006, pages 621 - 681, XP055151376, DOI: 10.1124/pr.58.3.10
HUANG, D.: "HIF-1-mediated suppression of acyl-CoA dehydrogenases and fatty acid oxidation is critical for cancer progression", CELL REP, vol. 8, 2014, pages 1930 - 1942
See also references of EP 4098647A4
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
Download PDF:
Previous Patent: HEIGHT-ADJUSTABLE SPINAL FUSION CAGE
Next Patent: STIMULATION TREATMENT DEVICE USING MAGNETIC FIELD
Next Patent: STIMULATION TREATMENT DEVICE USING MAGNETIC FIELD