Title:
DISULFIRAM-CONTAINING ACTIVITY INHIBITOR FOR GROUP 2 INNATE LYMPHOID CELL (ILC2)
Document Type and Number:
WIPO Patent Application WO/2020/054821
Kind Code:
A1
Abstract:
The present invention addresses the problem of developing, by focusing on the central role of group 2 innate lymphoid cells (ILC2) in the immune system, a drug that is capable of inhibiting the activity of ILC2. The present invention has discovered that disulfiram is capable of inhibiting activity and/or multiplication of ILC2, and provides an ILC2 activity inhibitor containing disulfiram.
Inventors:
FUKUNAGA KOICHI (JP)
MATSUSAKA MASAKO (JP)
KABATA HIROKI (JP)
MATSUSAKA MASAKO (JP)
KABATA HIROKI (JP)
Application Number:
PCT/JP2019/035970
Publication Date:
March 19, 2020
Filing Date:
September 12, 2019
Export Citation:
Assignee:
UNIV KEIO (JP)
International Classes:
A61K31/145; A61P1/04; A61P1/16; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P13/10; A61P17/00; A61P21/00; A61P31/12; A61P31/16; A61P33/00; A61P35/00; A61P37/00; A61P37/06; A61P43/00
Domestic Patent References:
| WO2001051046A1 | 2001-07-19 |
Other References:
ZHAO, A. ET AL.: "Disulfiram inhibits TNF-alpha- induced cell death", CYTOKINE, vol. 12, no. 9, September 2000 (2000-09-01), pages 1356 - 1367, XP055617449, ISSN: 1043-4666, DOI: 10.1006/cyto.2000.0725
TRIFILIEFF, A. ET AL.: "Fas-induced death of a murine pulmonary epithelial cell line: modulation by inflammatory cytokines", FUNDAMENTAL CLINICAL PHARMACOLOGY, vol. 13, no. 6, December 1999 (1999-12-01), pages 656 - 661, XP055693199, ISSN: 1472-8206
ISHIMARU, NAOZUMI ET AL.: "Therapeutic effect of fosfomycin in animal model of sjogren's syndrome", JAPANESE JOURNAL OF CHEMOTHERAPY, vol. 48, no. 10, October 2000 (2000-10-01), pages 775 - 779, ISSN: 1884-5886
TRIFILIEFF, A. ET AL.: "Fas-induced death of a murine pulmonary epithelial cell line: modulation by inflammatory cytokines", FUNDAMENTAL CLINICAL PHARMACOLOGY, vol. 13, no. 6, December 1999 (1999-12-01), pages 656 - 661, XP055693199, ISSN: 1472-8206
ISHIMARU, NAOZUMI ET AL.: "Therapeutic effect of fosfomycin in animal model of sjogren's syndrome", JAPANESE JOURNAL OF CHEMOTHERAPY, vol. 48, no. 10, October 2000 (2000-10-01), pages 775 - 779, ISSN: 1884-5886
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
Download PDF:
Previous Patent: RESIN COMPOSITION AND MOLDED BODY THEREOF
Next Patent: SOUND ANALYSIS DEVICE, PROCESSING METHOD THEREOF, AND PROGRAM
Next Patent: SOUND ANALYSIS DEVICE, PROCESSING METHOD THEREOF, AND PROGRAM