Title:
DNA POLYMERASE-BASED GENOME EDITING SYSTEM AND METHOD
Document Type and Number:
WIPO Patent Application WO/2024/051850
Kind Code:
A1
Abstract:
The present invention relates to a DNA polymerase-based genome site-directed modification method. More specifically, the present invention relates to a method for binding a DNA polymerase to a sequence-specific nucleic acid and simultaneously providing a DNA template sequence carrying the required modification, to achieve site-directed introduction of the target modification into a genome.
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Inventors:
GAO CAIXIA (CN)
LIN QIUPENG (CN)
LIU GUANWEN (CN)
ZHAO KEVIN T (CN)
LIN QIUPENG (CN)
LIU GUANWEN (CN)
ZHAO KEVIN T (CN)
Application Number:
PCT/CN2023/117975
Publication Date:
March 14, 2024
Filing Date:
September 11, 2023
Export Citation:
Assignee:
INST GENETICS & DEVELOPMENTAL BIOLOGY CAS (CN)
BEIJING QI BIODESIGN BIOTECHNOLOGY COMPANY LTD (CN)
BEIJING QI BIODESIGN BIOTECHNOLOGY COMPANY LTD (CN)
International Classes:
C12N15/90; C12N9/22; C12N15/115; C12N15/62
Domestic Patent References:
| WO2016155482A1 | 2016-10-06 | |||
| WO2018149418A1 | 2018-08-23 | |||
| WO2021032155A1 | 2021-02-25 |
Foreign References:
| CN109266648A | 2019-01-25 | |||
| CN114807240A | 2022-07-29 |
Other References:
YOO, K. W. ET AL.: "Targeting DNA polymerase to DNA double-strand breaks reduces DNA deletion size and increases templated insertions generated by CRISPR/Cas9", NUCLEIC ACIDS RESEARCH, vol. 50, no. 7, 22 March 2022 (2022-03-22), pages 3944 - 3957, XP093110396, DOI: 10.1093/nar/gkac186
SHAN, QIWEI; CAIXIA, GAO: "Research Progress of Genome Editing And Derivative Technologies in Plants", HEREDITAS, ZHONGGUO YICHUAN XUEHUI KEXUE, BEJING, CN, vol. 37, no. 10, 31 October 2015 (2015-10-31), CN , pages 953 - 973, XP009553686, ISSN: 0253-9772, DOI: 10.16288/j.yczz.15-156
SHAN, QIWEI; CAIXIA, GAO: "Research Progress of Genome Editing And Derivative Technologies in Plants", HEREDITAS, ZHONGGUO YICHUAN XUEHUI KEXUE, BEJING, CN, vol. 37, no. 10, 31 October 2015 (2015-10-31), CN , pages 953 - 973, XP009553686, ISSN: 0253-9772, DOI: 10.16288/j.yczz.15-156
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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