Title:
DOUBLE COMPOSITE TABLET FOR ORAL ADMINISTRATION CONTAINING TRAMADOL AND CELECOXIB
Document Type and Number:
WIPO Patent Application WO/2018/186650
Kind Code:
A3
Abstract:
The present invention relates to a double composite tablet for oral administration, comprising: a sustained release layer containing tramadol as an active ingredient; and an immediate release layer containing celecoxib as an active ingredient, wherein the double composite tablet is an oral preparation that is prescribed for alleviation of symptoms or signs of osteoarthritis (degenerative arthritis), alleviation of symptoms or sings of rheumatoid arthritis, alleviation of symptoms or signs of ankylosing spondylitis, relief of acute pain in adults (post-operative or post-extraction pain), primary dysmenorrhea, or severe and moderate acute or chronic pain. Through the present invention, a composition for pain treatment can be provided that reduces side effects of tramadol and has a continuous pain-killing effect for 12 hours by sustainedly releasing tramadol with solubility in water and immediately releasing celecoxib with poor solubility. Furthermore, the number of drugs administered is decreased by preparing two kinds of drugs into a single complex preparation, thereby improving the convenience of drug administration.
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Inventors:
KIM SUNG HYUN (KR)
HWANG SUNG JOO (KR)
AHN JUN HYUN (KR)
HYUN SANG MIN (KR)
KWAK SANG WON (KR)
SUN BO KYUNG (KR)
HWANG SUNG JOO (KR)
AHN JUN HYUN (KR)
HYUN SANG MIN (KR)
KWAK SANG WON (KR)
SUN BO KYUNG (KR)
Application Number:
PCT/KR2018/003905
Publication Date:
January 03, 2019
Filing Date:
April 03, 2018
Export Citation:
Assignee:
KIMS HEALTHCARE CO LTD (KR)
UNIV YONSEI IACF (KR)
UNIV YONSEI IACF (KR)
International Classes:
A61K9/24; A61K9/20; A61K31/135; A61K31/415
Foreign References:
| KR101710792B1 | 2017-02-28 | |||
| KR20120089287A | 2012-08-09 |
Other References:
KODAM, DEEPTHI ET AL.: "Formulation and Evaluation of Tramadol Hydrochloride Sustained Matrix Tablets", SCHOLARS RESEARCH LIBRARY, DER PHARMACIO LETTER, vol. 3, no. 3, 2011, pages 245 - 249, XP055560093
RAO, P. SAMBA SIVA ET AL.: "Formulation and Evaluation of Tramadol Hcl Sustained Released Pellets", INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY, vol. 5, no. 3, 2015, pages 413 - 419, XP055560101
REHMAN, ASIM.UR ET AL.: "Formulation and Evaluation of Tramadol HCL Matrix Tablets Using Carbopol 974P and 934 as Rate-controlling Agents", TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, vol. 12, no. 2, 2013, pages 169 - 172, XP055560103
RAO, P. SAMBA SIVA ET AL.: "Formulation and Evaluation of Tramadol Hcl Sustained Released Pellets", INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY, vol. 5, no. 3, 2015, pages 413 - 419, XP055560101
REHMAN, ASIM.UR ET AL.: "Formulation and Evaluation of Tramadol HCL Matrix Tablets Using Carbopol 974P and 934 as Rate-controlling Agents", TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, vol. 12, no. 2, 2013, pages 169 - 172, XP055560103
Attorney, Agent or Firm:
NAMCHON INTERNATIONAL PATENT AND LAW FIRM (KR)
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