Title:
DPP-4 INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2013/065832
Kind Code:
A1
Abstract:
A DPP-4 inhibitor containing, as an active ingredient, a peptide represented by formula (1): Xe-Pro/Ala/Hyp-Xa-Xb-Xc-Xd (wherein Xe represents an amino acid residue having an isoelectric point of 5.9-6.3; Pro/Ala/Hyp represents Pro, Ala or Hyp; Xa represents an amino acid residue other than Hyp, Pro and Arg or a deletion; Xb represents Gly, Pro or a deletion; Xc represents Pro, Ala or a deletion; and Xd represents an amino acid residue or a deletion). This inhibitor is expected to exert an activity of decreasing a blood glucose level through the potentiation of the activity of an incretin, and therefore can be used as a therapeutic agent for diabetes. In addition, this inhibitor can act on an immune system or the like, and therefore can be used for the treatment of skin diseases or the like.
Inventors:
HAYASHIDA OSAMU (JP)
KUSUBATA MASASHI (JP)
ATSUZAWA YUJI (JP)
TAGA YUKI (JP)
KOYAMA YOUICHI (JP)
HATTORI SHUNJI (JP)
KUSUBATA MASASHI (JP)
ATSUZAWA YUJI (JP)
TAGA YUKI (JP)
KOYAMA YOUICHI (JP)
HATTORI SHUNJI (JP)
Application Number:
PCT/JP2012/078511
Publication Date:
May 10, 2013
Filing Date:
November 02, 2012
Export Citation:
Assignee:
NIPPI INC (JP)
International Classes:
C07K5/062; C07K7/06; C07K5/083; C07K5/103; C12N9/99
Domestic Patent References:
| WO2008066070A1 | 2008-06-05 | |||
| WO2012102308A1 | 2012-08-02 |
Foreign References:
| JP2011201923A | 2011-10-13 | |||
| JP2011182742A | 2011-09-22 |
Other References:
TORU OTA ET AL.: "DPPIV Sogai Proline Gan'yu Peptide no Kensaku Oyobi Gosei no Kento", THE JAPANESE SOCIETY FOR FOOD SCIENCE AND TECHNOLOGY DAI 57 KAI TAIKAI KOENSHU, 1 September 2010 (2010-09-01), pages 74
Attorney, Agent or Firm:
KIMURA MITSURU (JP)
Mitsuru Kimura (JP)
Mitsuru Kimura (JP)
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Claims: