Title:
DRUG COMPOSITION FOR ANGIOGENESIS THERAPY
Document Type and Number:
WIPO Patent Application WO/2011/024480
Kind Code:
A1
Abstract:
Disclosed is a drug composition for angiogenesis therapy that is useful in the treatment or prevention of peripheral arterial diseases; wherein the drug composition is provided with an adeno-associated virus (AAV) that comprises a human prostacyclin synthase (hPGIS) gene responsible for prostaglandin I2 (PGI2), which is a substance having vasodilator action and/or platelet aggregation inhibiting activity, and also comprises a gene that encodes angiogenesis factors. By administering the drug composition to sites that are the objective of therapy, gene introduction into AAV type 1-hPGIS skeletal muscles is achieved, prominent human PGIS gene expression is caused within the skeletal muscle cells, the PGI2 produced and secreted from the muscle cells through the gene expression causes vascular protection activity and angiogenesis-inducing activity, and vascular ischemia is ameliorated.
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Inventors:
HUKUDA KEIICHI (JP)
KAWAKAMI TAKASHI (JP)
TANABE TADASHI (JP)
KAWAKAMI TAKASHI (JP)
TANABE TADASHI (JP)
Application Number:
PCT/JP2010/005321
Publication Date:
March 03, 2011
Filing Date:
August 30, 2010
Export Citation:
Assignee:
HUKUDA KEIICHI (JP)
KAWAKAMI TAKASHI (JP)
TANABE TADASHI (JP)
KAWAKAMI TAKASHI (JP)
TANABE TADASHI (JP)
International Classes:
A61K48/00; A61K31/5585; A61K35/76; A61K38/22; A61K38/43; A61P7/02; A61P9/00; A61P9/08; A61P43/00; A61K35/13
Domestic Patent References:
| WO2002000258A1 | 2002-01-03 | |||
| WO2002000258A1 | 2002-01-03 | |||
| WO1997007824A1 | 1997-03-06 | |||
| WO1995030013A1 | 1995-11-09 |
Other References:
KAWAKAMI T. ET AL: "Gene Therapy Using AAV-PGIS Vector Improves a Necrosis of Limb Ischemia", CIRC. J., vol. 74, no. 1, 1 March 2010 (2010-03-01), pages 623, XP008152842
KAWAKAMI T. ET AL: "Adeno-associated Virus- mediated Prostaglandin 12 Synthase (PGIS) Gene Transfer Improves a Limb Ischemia", CIRC. J., vol. 73, no. 1, 1 March 2009 (2009-03-01), pages 592 - 593, XP008152843
HIRAOKA K. ET AL: "Enhanced therapeutic angiogenesis by cotransfection of prostacyclin synthase gene or optimization of intramuscular injection of naked plasmid DNA", CIRCULATION, vol. 108, no. 21, 2003, pages 2689 - 2696, XP002538899
KAWAKAMI T. ET AL: "AAV-PGIS gene transfer improves hypoxia-induced pulmonary hypertension in mice", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 363, no. 3, 2007, pages 656 - 661, XP022288910
YAN H. ET AL: "Superior neovascularization and muscle regeneration in ischemic skeletal muscles following VEGF gene transfer by rAAV1 pseudotyped vectors", BIOCHEM BIOPHYS RES COMMUN, vol. 336, no. 1, 2005, pages 287 - 298, XP027229809
HAUCK B. ET AL: "Characterization of tissue tropism determinants of adeno-associated virus type 1", J. VIROL., vol. 77, no. 4, 2003, pages 2768 - 2774, XP002400210
CIRCULATION, vol. 90, 1994, pages 11 - 228,11-234
SCIENCE, vol. 219, 1983, pages 983
J. CLIN. INVEST., vol. 84, 1989, pages 1470
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 161, 1989, pages 851
SCIENCE, vol. 246, 1989, pages 1306
B.B.R.C., vol. 200, no. 3, 1994, pages 1728 - 1734
"Separate Volume Jikken-igaku, Fundamental Technique for Gene Therapy", 1997, YODOSHA CO
"Separate Volume Jikken-igaku, Experimental Mehods for Gene Transfer and Expression Analyses", 1997, YODOSHA CO
"Handbook for R&D of Gene Therapy", 1999, NTS CO.
NIKKEI SCIENCE (IN JAPANESE, April 1994 (1994-04-01), pages 20 - 45
GEKKANYAKUJI (IN JAPANESE, vol. 36, no. 1, 1994, pages 23 - 48
JIKKEN-IGAKU, vol. 12, no. 15, 1994
"Handbook for R&D of Gene Therapy (in Japanese", 1999, NTS CO.
See also references of EP 2474325A4
KAWAKAMI T. ET AL: "Adeno-associated Virus- mediated Prostaglandin 12 Synthase (PGIS) Gene Transfer Improves a Limb Ischemia", CIRC. J., vol. 73, no. 1, 1 March 2009 (2009-03-01), pages 592 - 593, XP008152843
HIRAOKA K. ET AL: "Enhanced therapeutic angiogenesis by cotransfection of prostacyclin synthase gene or optimization of intramuscular injection of naked plasmid DNA", CIRCULATION, vol. 108, no. 21, 2003, pages 2689 - 2696, XP002538899
KAWAKAMI T. ET AL: "AAV-PGIS gene transfer improves hypoxia-induced pulmonary hypertension in mice", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 363, no. 3, 2007, pages 656 - 661, XP022288910
YAN H. ET AL: "Superior neovascularization and muscle regeneration in ischemic skeletal muscles following VEGF gene transfer by rAAV1 pseudotyped vectors", BIOCHEM BIOPHYS RES COMMUN, vol. 336, no. 1, 2005, pages 287 - 298, XP027229809
HAUCK B. ET AL: "Characterization of tissue tropism determinants of adeno-associated virus type 1", J. VIROL., vol. 77, no. 4, 2003, pages 2768 - 2774, XP002400210
CIRCULATION, vol. 90, 1994, pages 11 - 228,11-234
SCIENCE, vol. 219, 1983, pages 983
J. CLIN. INVEST., vol. 84, 1989, pages 1470
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 161, 1989, pages 851
SCIENCE, vol. 246, 1989, pages 1306
B.B.R.C., vol. 200, no. 3, 1994, pages 1728 - 1734
"Separate Volume Jikken-igaku, Fundamental Technique for Gene Therapy", 1997, YODOSHA CO
"Separate Volume Jikken-igaku, Experimental Mehods for Gene Transfer and Expression Analyses", 1997, YODOSHA CO
"Handbook for R&D of Gene Therapy", 1999, NTS CO.
NIKKEI SCIENCE (IN JAPANESE, April 1994 (1994-04-01), pages 20 - 45
GEKKANYAKUJI (IN JAPANESE, vol. 36, no. 1, 1994, pages 23 - 48
JIKKEN-IGAKU, vol. 12, no. 15, 1994
"Handbook for R&D of Gene Therapy (in Japanese", 1999, NTS CO.
See also references of EP 2474325A4
Attorney, Agent or Firm:
TAMURA, EIICHI (JP)
Eiichi Tamura (JP)
Eiichi Tamura (JP)
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