DRUG DELIVERY POLYMER MICELLES - KYOTO PHARMACEUTICAL UNIV

Title:

DRUG DELIVERY POLYMER MICELLES

Document Type and Number:

WIPO Patent Application WO/2019/009434

Kind Code:

A1

Abstract:

The present invention relates to: a compound that is formed by linking the α carbonyl group of aspartic acid directly or via a linker to at least 50% of all of the terminal groups of a dendritic polymer that has a plurality of terminal groups by means of a peptide bond or an ester linkage, by linking a hydrophilic polymer segment directly or via a linker to at least 3% of the total of the terminal amino groups from the aspartic acid and the terminal groups of the dendritic polymer not modified with aspartic acid, and linking a hydrophobic segment directly or via a linker to at least 1% of the total of the terminal amino groups from the aspartic acid and the terminal groups of the dendritic polymer not modified with aspartic acid; and a drug delivery carrier that comprises polymer micelles that self-assemble from the compound. The drug delivery carrier forms micelles when mixed with a drug and thereby makes it possible for the drug to be selectively delivered to bones, which makes it possible to provide useful medicine for the treatment of various bone diseases.

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Inventors:

KATSUMI HIDEMASA (JP)
YAMAMOTO AKIRA (JP)

Application Number:

PCT/JP2018/026250

Publication Date:

January 10, 2019

Filing Date:

July 06, 2018

Export Citation:

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Assignee:

KYOTO PHARMACEUTICAL UNIV (JP)

International Classes:

C08G81/00; A61K9/107; A61K45/00; A61K47/28; A61K47/34; A61K47/62; A61K48/00; A61K49/00; A61K51/00; A61P19/10; A61P29/00; A61P35/00

Domestic Patent References:

WO2016093352A1	2016-06-16
WO2016209732A1	2016-12-29

Foreign References:

JP2011162452A	2011-08-25
US20120003322A1	2012-01-05
US20130136697A1	2013-05-30
JP2014514431A	2014-06-19
JP2014525459A	2014-09-29
JP2017105802A	2017-06-15

Attorney, Agent or Firm:

TAKASHIMA, Hajime et al. (JP)

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