Title:
DRUG DELIVERY PROMOTER CONTAINING SUBSTANCE FOR ACTIVATING LYSOPHOSPHOLIPID RECEPTORS
Document Type and Number:
WIPO Patent Application WO/2015/152412
Kind Code:
A1
Abstract:
The present invention provides: a drug delivery promoter for promoting the delivery of a drug for the treatment of diseases associated with angiodysplasia to an affected site, the drug delivery promoter containing as an active ingredient a substance that activates lysophospholipid receptors; a pharmaceutical composition for the treatment of diseases associated with angiodysplasia, the pharmaceutical composition containing as an active ingredient a substance that activates lysophospholipid receptors; and a method for screening drugs for the treatment of diseases associated with angiodysplasia, the method being characterized in that a substance that activates lysophospholipid receptors is selected, the substance being expressed specifically in vascular endothelial cells at the affected site.
Inventors:
TAKAKURA NOBUYUKI (JP)
NAITO HISAMICHI (JP)
TAKARA KAZUHIRO (JP)
NAITO HISAMICHI (JP)
TAKARA KAZUHIRO (JP)
Application Number:
PCT/JP2015/060666
Publication Date:
October 08, 2015
Filing Date:
April 03, 2015
Export Citation:
Assignee:
UNIV OSAKA (JP)
International Classes:
A61K45/00; A61K45/06; A61K47/24; A61P9/10; A61P13/12; A61P17/00; A61P17/04; A61P17/06; A61P19/02; A61P27/02; A61P29/00; A61P35/00; A61P37/08; A61P43/00
Domestic Patent References:
| WO2003007991A1 | 2003-01-30 |
Foreign References:
| JPH11506780A | 1999-06-15 | |||
| JPH08505403A | 1996-06-11 | |||
| JPH08500816A | 1996-01-30 | |||
| JP2005170819A | 2005-06-30 | |||
| JPS63152327A | 1988-06-24 | |||
| JPS57145811A | 1982-09-09 | |||
| JP2004526803A | 2004-09-02 | |||
| JP2009500401A | 2009-01-08 | |||
| JP2011513418A | 2011-04-28 |
Other References:
XUN QI ET AL.: "Sustained delivery of sphingosine-1-phosphate using poly(lactic-co- glycolic acid)-based microparticles stimulates Akt/ERK-eNOS mediated angiogenesis and vascular maturation restoring blood flow in inschemic limbs of mice", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 634, no. 1-3, 2010, pages 121 - 131, XP055228870, ISSN: 0014-2999
See also references of EP 3135297A4
See also references of EP 3135297A4
Attorney, Agent or Firm:
IWATANI, Ryo (JP)
Tatsu Iwatani (JP)
Tatsu Iwatani (JP)
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