Title:
DRUG FOR TREATING SITH-1-ASSOCIATED DISEASES
Document Type and Number:
WIPO Patent Application WO/2023/127600
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a novel drug for treating SITH-1-associated diseases. The problem is solved by a drug for treating SITH-1-associated diseases, the drug containing a cholinergic agonist as an active ingredient.
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Inventors:
KONDO KAZUHIRO (JP)
OKA NAOMI (JP)
OKA NAOMI (JP)
Application Number:
PCT/JP2022/046876
Publication Date:
July 06, 2023
Filing Date:
December 20, 2022
Export Citation:
Assignee:
VIRUS IKAGAKU KENKYUSHO INC (JP)
International Classes:
A61K45/00; A01K67/027; A61K31/445; A61P3/02; A61P25/24; A61P43/00
Other References:
PAPP MARIUSZ; GRUCA PIOTR; LASON-TYBURKIEWICZ MAGDALENA; WILLNER PAUL: "Antidepressant, anxiolytic and procognitive effects of rivastigmine and donepezil in the chronic mild stress model in rats", PSYCHOPHARMACOLOGY, SPRINGER VERLAG, BERLIN., DE, vol. 233, no. 7, 15 January 2016 (2016-01-15), DE , pages 1235 - 1243, XP035867266, ISSN: 0033-3158, DOI: 10.1007/s00213-016-4206-0
PAN YING, WEI-YUN ZHANG, XING XIA, LING-DONG KONG: "Effects of Icariin on Hypothalamic-Pituitary-Adrenal Axis Action and Cytokine Levels in Stressed Sprague-Dawley Rats", BIOL. PHARM. BULL., vol. 29, no. 12, 1 December 2006 (2006-12-01), pages 2399 - 2403, XP093075989
HE, X.L. ; ZHOU, W.Q. ; BI, M.G. ; DU, G.H.: "Neuroprotective effects of icariin on memory impairment and neurochemical deficits in senescence-accelerated mouse prone 8 (SAMP8) mice", BRAIN RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 1334, 2 June 2010 (2010-06-02), NL , pages 73 - 83, XP027047158, ISSN: 0006-8993
LEE DONG-YUN, KIM JEON-KYUNG, YUN SOO-WON, HAN MYUNG JOO, KIM DONG-HYUN: "DW2009 Elevates the Efficacy of Donepezil against Cognitive Impairment in Mice", NUTRIENTS, vol. 13, no. 9, pages 3273, XP093075992, DOI: 10.3390/nu13093273
XIAO JUNHUA, ZHANG GUFANG, GAO SUJUN, SHEN JIAQING, FENG HUANG, HE ZHILONG, XU CHUNFANG: "Combined administration of SHP2 inhibitor SHP099 and the α7nAChR agonist PNU282987 protect mice against DSS‑induced colitis", MOLECULAR MEDICINE REPORTS, SPANDIDOS PUBLICATIONS, GR, vol. 22, no. 3, GR , pages 2235 - 2244, XP093075993, ISSN: 1791-2997, DOI: 10.3892/mmr.2020.11324
ZHANG HAORAN, ZHUO SHIXUAN, SONG DANNI, WANG LEYAO, GU JUNYI, MA JUNYAN, GU YANG, JI MINGHUI, CHEN MEIJUAN, GUO YUANYUAN: "Icariin Inhibits Intestinal Inflammation of DSS-Induced Colitis Mice Through Modulating Intestinal Flora Abundance and Modulating p-p65/p65 Molecule", THE TURKISH JOURNAL OF GASTROENTEROLOGY, vol. 32, no. 4, pages 382 - 392, XP093075995, DOI: 10.5152/tjg.2021.20282
SINGH SHASHI P.; CHAND HITENDRA S.; BANERJEE SANTANU; AGARWAL HEMANT; RAIZADA VEENA; ROY SABITA; SOPORI MOHAN: "Acetylcholinesterase Inhibitor Pyridostigmine Bromide Attenuates Gut Pathology and Bacterial Dysbiosis in a Murine Model of Ulcerative Colitis", DIGESTIVE DISEASES AND SCIENCES., SPRINGER NEW YORK LLC, US, vol. 65, no. 1, 23 October 2019 (2019-10-23), US , pages 141 - 149, XP036979991, ISSN: 0163-2116, DOI: 10.1007/s10620-019-05838-6
GHIA, J. ; BLENNERHASSETT, P. ; DENG, Y. ; VERDU, E.F. ; KHAN, W.I. ; COLLINS, S.M.: "Reactivation of Inflammatory Bowel Disease in a Mouse Model of Depression", GASTROENTEROLOGY, ELSEVIER INC., US, vol. 136, no. 7, 1 June 2009 (2009-06-01), US , pages 2280 - 2288.e4, XP026168945, ISSN: 0016-5085, DOI: 10.1053/j.gastro.2009.02.069
KOBAYASHI NOBUYUKI, NAOMI OKA, MAYUMI TAKAHASHI, MASAHIRO SHIGETA, HIROYUKI YANAGISAWA, KAZUHIRO KONDO: "Human Herpesvirus 6B Greatly Increases Risk of Depression by Activating Hypothalamic-Pituitary -Adrenal Axis during Latent Phase of Infection", ISCIENCE, ELSEVIER, vol. 23, 26 June 2020 (2020-06-26), pages 101187, XP093076000, DOI: 10.1016/ j.isci.2020.101187
KONDO KAZUHIRO: "Molecular mechanism of fatigue and mood disorders", JAPANESE JOURNAL OF BIOLOGICAL PSYCHIATRY, vol. 24, no. 4, 1 January 2013 (2013-01-01), pages 218 - 221, XP093076004, DOI: 10.11249/jsbpjjpp.24.4_218
PAN YING, WEI-YUN ZHANG, XING XIA, LING-DONG KONG: "Effects of Icariin on Hypothalamic-Pituitary-Adrenal Axis Action and Cytokine Levels in Stressed Sprague-Dawley Rats", BIOL. PHARM. BULL., vol. 29, no. 12, 1 December 2006 (2006-12-01), pages 2399 - 2403, XP093075989
HE, X.L. ; ZHOU, W.Q. ; BI, M.G. ; DU, G.H.: "Neuroprotective effects of icariin on memory impairment and neurochemical deficits in senescence-accelerated mouse prone 8 (SAMP8) mice", BRAIN RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 1334, 2 June 2010 (2010-06-02), NL , pages 73 - 83, XP027047158, ISSN: 0006-8993
LEE DONG-YUN, KIM JEON-KYUNG, YUN SOO-WON, HAN MYUNG JOO, KIM DONG-HYUN: "DW2009 Elevates the Efficacy of Donepezil against Cognitive Impairment in Mice", NUTRIENTS, vol. 13, no. 9, pages 3273, XP093075992, DOI: 10.3390/nu13093273
XIAO JUNHUA, ZHANG GUFANG, GAO SUJUN, SHEN JIAQING, FENG HUANG, HE ZHILONG, XU CHUNFANG: "Combined administration of SHP2 inhibitor SHP099 and the α7nAChR agonist PNU282987 protect mice against DSS‑induced colitis", MOLECULAR MEDICINE REPORTS, SPANDIDOS PUBLICATIONS, GR, vol. 22, no. 3, GR , pages 2235 - 2244, XP093075993, ISSN: 1791-2997, DOI: 10.3892/mmr.2020.11324
ZHANG HAORAN, ZHUO SHIXUAN, SONG DANNI, WANG LEYAO, GU JUNYI, MA JUNYAN, GU YANG, JI MINGHUI, CHEN MEIJUAN, GUO YUANYUAN: "Icariin Inhibits Intestinal Inflammation of DSS-Induced Colitis Mice Through Modulating Intestinal Flora Abundance and Modulating p-p65/p65 Molecule", THE TURKISH JOURNAL OF GASTROENTEROLOGY, vol. 32, no. 4, pages 382 - 392, XP093075995, DOI: 10.5152/tjg.2021.20282
SINGH SHASHI P.; CHAND HITENDRA S.; BANERJEE SANTANU; AGARWAL HEMANT; RAIZADA VEENA; ROY SABITA; SOPORI MOHAN: "Acetylcholinesterase Inhibitor Pyridostigmine Bromide Attenuates Gut Pathology and Bacterial Dysbiosis in a Murine Model of Ulcerative Colitis", DIGESTIVE DISEASES AND SCIENCES., SPRINGER NEW YORK LLC, US, vol. 65, no. 1, 23 October 2019 (2019-10-23), US , pages 141 - 149, XP036979991, ISSN: 0163-2116, DOI: 10.1007/s10620-019-05838-6
GHIA, J. ; BLENNERHASSETT, P. ; DENG, Y. ; VERDU, E.F. ; KHAN, W.I. ; COLLINS, S.M.: "Reactivation of Inflammatory Bowel Disease in a Mouse Model of Depression", GASTROENTEROLOGY, ELSEVIER INC., US, vol. 136, no. 7, 1 June 2009 (2009-06-01), US , pages 2280 - 2288.e4, XP026168945, ISSN: 0016-5085, DOI: 10.1053/j.gastro.2009.02.069
KOBAYASHI NOBUYUKI, NAOMI OKA, MAYUMI TAKAHASHI, MASAHIRO SHIGETA, HIROYUKI YANAGISAWA, KAZUHIRO KONDO: "Human Herpesvirus 6B Greatly Increases Risk of Depression by Activating Hypothalamic-Pituitary -Adrenal Axis during Latent Phase of Infection", ISCIENCE, ELSEVIER, vol. 23, 26 June 2020 (2020-06-26), pages 101187, XP093076000, DOI: 10.1016/ j.isci.2020.101187
KONDO KAZUHIRO: "Molecular mechanism of fatigue and mood disorders", JAPANESE JOURNAL OF BIOLOGICAL PSYCHIATRY, vol. 24, no. 4, 1 January 2013 (2013-01-01), pages 218 - 221, XP093076004, DOI: 10.11249/jsbpjjpp.24.4_218
Attorney, Agent or Firm:
HARAKENZO WORLD PATENT & TRADEMARK (JP)
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