Title:
DYE-AZIDE COMPOUNDS FOR DUAL PHOTOTHERAPY
Document Type and Number:
WIPO Patent Application WO2003003806
Kind Code:
A3
Abstract:
The present invention discloses dye-azide derivatives and their bioconjugates for dual phototherapy of tumors and other lesions. The compounds of the present invention may contain either a mixture of Type 1 and Type 2 agents or a single entity that integrates both units in the same molecules. The compounds are designed to produce both Type 1 and Type 2 phototherapeutic effect at once using dual wavelength light source that will produce singlet oxygen and nitrene at the lesion of interest.
Inventors:
RAJAGOPALAN RAGHAVAN (US)
ACHILEFU SAMUEL I (US)
BUGAJ JOSEPH E (US)
DORSHOW RICHARD B (US)
ACHILEFU SAMUEL I (US)
BUGAJ JOSEPH E (US)
DORSHOW RICHARD B (US)
Application Number:
PCT/US2002/019187
Publication Date:
April 08, 2004
Filing Date:
June 18, 2002
Export Citation:
Assignee:
MALLINCKRODT INC (US)
RAJAGOPALAN RAGHAVAN (US)
ACHILEFU SAMUEL I (US)
BUGAJ JOSEPH E (US)
DORSHOW RICHARD B (US)
RAJAGOPALAN RAGHAVAN (US)
ACHILEFU SAMUEL I (US)
BUGAJ JOSEPH E (US)
DORSHOW RICHARD B (US)
International Classes:
C07D277/64; A61K31/409; A61K31/428; A61K41/00; A61K45/00; A61K47/48; A61P9/10; A61P35/00; A61P43/00; C07D487/22; C09B47/04; (IPC1-7): C07D277/64; A61K33/44; C07K17/02; C12N11/02
Foreign References:
| US3887379A | 1975-06-03 | |||
| US6004536A | 1999-12-21 | |||
| US6077584A | 2000-06-20 | |||
| JPH11174672A | 1999-07-02 |
Other References:
DATABASE HCAPLUS [online] OL'SHEVSKAYA I. ET AL.: "Synthesis and reactions of azides of heterocyclic compounds. III. Cyanine dyes from azidobenzothiazole and benzimidazole", XP002973715, Database accession no. 1974:522751
DATABASE HCAPLUS [online] POCHINOK V. ET AL.: "Photochemistry of azide group-containing dyes in solution", XP002973711, accession no. STN Database accession no. 1984:439817
DATABASE HCAPLUS [online] POCHINOK V. ET AL.: "Photochemistry of azide group-containing dyes in solution", XP002973711, accession no. STN Database accession no. 1984:439817
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