Title:
ELECTROCHEMICAL PREPARATION METHOD FOR Β-TRIFLUOROMETHYLAMIDE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2020/147861
Kind Code:
A1
Abstract:
Disclosed is an electrochemical preparation method for a β-trifluoromethylamide compound, comprising the following steps: using an arylacetylene compound and a trifluoromethyl source as raw materials, and preparing the β-trifluoromethylamide compound by means of electrochemical anodic oxidation. Said preparation method further comprises a step of purifying the product prepared by electrochemical anodic oxidation, the purification treatment process comprising: adding ethyl acetate to quench the reaction after the reaction is completed, adding saturated brine to perform washing, separating the organic phases from the aqueous phase, performing extraction on the aqueous phase using ethyl acetate 3 to 5 times, combining the organic phases, adding anhydrous sodium sulfate for drying, removing the solvent by distillation under reduced pressure, and performing column chromatography to obtain the β-trifluoromethylamide compound having higher purity. Compared with the prior art, the solution of the present invention has the advantages of such as a simple operation, low production costs, and a high yield.
Inventors:
HUANG YUBING (CN)
LU JINGJUN (CN)
JIANG HONG (CN)
LI YIBIAO (CN)
ZHU ZHONGZHI (CN)
CHEN XIUWEN (CN)
LU JINGJUN (CN)
JIANG HONG (CN)
LI YIBIAO (CN)
ZHU ZHONGZHI (CN)
CHEN XIUWEN (CN)
Application Number:
PCT/CN2020/073672
Publication Date:
July 23, 2020
Filing Date:
January 22, 2020
Export Citation:
Assignee:
UNIV WUYI (CN)
International Classes:
C25B3/23
Foreign References:
| CN109972165A | 2019-07-05 | |||
| JP2018135274A | 2018-08-30 | |||
| JP2014159382A | 2014-09-04 |
Other References:
LINGLING ZHANG, GUOTING ZHANG, PAN WANG, YONGLI LI, AIWEN LE: "Electrochemical Oxidation with Lewis-Acid Catalysis Leads to Trifluoromethylative Difunctionalization of Alkenes Using CF3SO2Na", ORGANIC LETTERS, vol. 20, no. 23, 21 November 2018 (2018-11-21), pages 7396 - 7399, XP055719720, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.8b03081
YUBING HUANG, HUANLIANG HONG, ZIRONG ZOU, CHUNSHU LIAO, JINGJUN LU, YONGWEI QIN, YIBIAO ,LU CHEN: "Electrochemical vicinal aminotrifluoromethylation of alkenes: high regioselective acquisition of β-trifluoromethylamines", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 17, no. 20, 25 April 2019 (2019-04-25), pages 5014 - 5020, XP055719722, ISSN: 1477-0520, DOI: 10.1039/C9OB00717B
YUBING HUANG, HUANLIANG HONG, ZIRONG ZOU, CHUNSHU LIAO, JINGJUN LU, YONGWEI QIN, YIBIAO ,LU CHEN: "Electrochemical vicinal aminotrifluoromethylation of alkenes: high regioselective acquisition of β-trifluoromethylamines", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 17, no. 20, 25 April 2019 (2019-04-25), pages 5014 - 5020, XP055719722, ISSN: 1477-0520, DOI: 10.1039/C9OB00717B
Attorney, Agent or Firm:
JIAQUAN IP LAW FIRM (CN)
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