β-ELEMENE DERIVATIVE WITH HDACI PHARMACOPHORE, AND PREPARATION METHOD THEREFOR AND USE THEREOF

WIPO Patent Application WO/2023/160039

A1

Disclosed in the present invention are a β-elemene derivative with an HDACi pharmacophore, and a preparation method therefor and the use thereof. Provided in the present invention are a β-elemene derivative with an HDACi pharmacophore having a structure as represented by formula (I), a pharmaceutical composition and hydrate containing a compound of formula (I), and an isotopic derivative, a chiral isomer, an allosteric substance, different salts, a prodrug, a preparation, etc., of the compounds. Further provided in the present invention are a method for preparing the β-elemene derivative with the HDACi pharmacophore, the use thereof, and the inhibitory activity of the compound on the proliferation of various tumor cell lines. The β-elemene derivative with the HDACi pharmacophore in the present invention is expected to become an antitumor drug candidate for treating various cancers, such as solid tumors and hematological tumors.

JPH06504031	INDUSTRIAL APPLICABILITY The title of the invention is an amino acid transport protein, an amino acid analog, an assay device, and its use in the treatment and diagnosis of cancer.
JPS56103129	MANUFACTURE OF SUBSTITUTED PHENYLHALOALKANOIC ACID AND ITS DERIVATIVE
WO/1993/013741	INHIBITION OF ANGIOGENESIS BY SYNTHETIC MATRIX METALLOPROTEASE INHIBITORS

XIE TIAN (CN)
YE XIANGYANG (CN)
GAO YUAN (CN)
ZHUO XIAOTAO (CN)
HE XINGRUI (CN)
BAI RENREN (CN)
DANG XIAWEN (CN)
YE YANG (CN)
LUO XINYU (CN)
XIANG HUAN (CN)
LIN YING (CN)

PCT/CN2022/132521

August 31, 2023

November 17, 2022

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UNIV HANGZHOU NORMAL (CN)

C07C259/06; A61K31/16; A61K31/397; A61K31/403; A61K31/407; A61K31/415; A61K31/44; A61K31/4439; A61K31/4468; A61K31/454; A61K31/495; A61K31/496; A61P35/00; A61P35/02; C07D205/04; C07D209/52; C07D211/58; C07D213/74; C07D213/78; C07D231/12; C07D295/155; C07D295/185; C07D401/08; C07D401/12; C07D403/08; C07D487/04

CN114591201A	2022-06-07
CN112707833A	2021-04-27
CN102746212A	2012-10-24
CN103848793A	2014-06-11
CN106866572A	2017-06-20
CN1153167A	1997-07-02
CN1153168A	1997-07-02
US20100222379A1	2010-09-02

BEIJING GAOWO LAW FIRM (CN)

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