Title:
ELISA KIT FOR CYP 2C9 METABOLIC PHENOTYPES
Document Type and Number:
WIPO Patent Application WO2003052425
Kind Code:
A3
Abstract:
The invention relates to an enzyme linked immunosorbent assay (ELISA) method and kit for the rapid determination of metabolic phenotypes for Cytochrome P450 2C9 (CYP 2C9). The kit uses may include but are not limited to, use on a routine basis in a clinical laboratory to determine a Cytochrome P450 2C9 (CYP 2C9) phenotype of an individual; to allow a physician to individualize an individual's treatment with respect to the numerous drugs e.g. ibuprofen, losartan, E-3174 and 2-carboxyibuprofen metabolized by CYP 2C9 based on a phenotypic determination; to predict an individual's susceptibility to carcinogen induced diseases including many cancers, and to screen individuals for a preferred metabolic phenotype in order to determine those individuals with a responsive phenotype for participation in clinical testing.
Inventors:
LEYLAND-JONES BRIAN (US)
Application Number:
PCT/CA2002/001965
Publication Date:
March 10, 2005
Filing Date:
December 18, 2002
Export Citation:
Assignee:
XANTHUS LIFE SCIENCES INC (US)
LEYLAND-JONES BRIAN (US)
LEYLAND-JONES BRIAN (US)
International Classes:
C12Q1/26; G01N33/50; G01N33/94; (IPC1-7): G01N33/94; C12Q1/26
Domestic Patent References:
| WO2002090994A2 | 2002-11-14 | |||
| WO2002071060A2 | 2002-09-12 | |||
| WO2000055624A2 | 2000-09-21 | |||
| WO2001011035A1 | 2001-02-15 |
Foreign References:
| EP1138779A2 | 2001-10-04 |
Other References:
GRAEFE K A ET AL: "Development and validation of an indirect enzyme-linked immunosorbent assay (ELISA) for the nonsteroidal anti-inflammatory drug S-ibuprofen.", PHARMAZIE, vol. 55, no. 4, April 2000 (2000-04-01), pages 286 - 292, XP001155342, ISSN: 0031-7144
BJORNSDOTTIR INGA ET AL: "Separation of the enantiomers of ibuprofen and its major phase I metabolites in urine using capillary electrophoresis.", ELECTROPHORESIS, vol. 19, no. 3, March 1998 (1998-03-01), pages 455 - 460, XP009018093, ISSN: 0173-0835
TAN S C ET AL: "Stereospecific analysis of the major metabolites of ibuprofen in urine by sequential achiral-chiral high-performance liquid chromatography", JOURNAL OF CHROMATOGRAPHY B: BIOMEDICAL SCIENCES & APPLICATIONS, ELSEVIER SCIENCE PUBLISHERS, NL, vol. 701, no. 1, 7 November 1997 (1997-11-07), pages 53 - 63, XP004095020, ISSN: 1570-0232
BJORNSDOTTIR INGA ET AL: "Separation of the enantiomers of ibuprofen and its major phase I metabolites in urine using capillary electrophoresis.", ELECTROPHORESIS, vol. 19, no. 3, March 1998 (1998-03-01), pages 455 - 460, XP009018093, ISSN: 0173-0835
TAN S C ET AL: "Stereospecific analysis of the major metabolites of ibuprofen in urine by sequential achiral-chiral high-performance liquid chromatography", JOURNAL OF CHROMATOGRAPHY B: BIOMEDICAL SCIENCES & APPLICATIONS, ELSEVIER SCIENCE PUBLISHERS, NL, vol. 701, no. 1, 7 November 1997 (1997-11-07), pages 53 - 63, XP004095020, ISSN: 1570-0232
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