Title:
ENGINEERED MICROORGANISM FOR PRODUCTION OLIVETOL AND OLIVETOLIC ACID
Document Type and Number:
WIPO Patent Application WO/2023/035527
Kind Code:
A1
Abstract:
Provided is engineered Escherichia coli for producing olivetol and olivetolic acid. An Escherichia coli fabH gene is deleted and an olivetol synthase is expressed, thereby improving the yield of olivetol and olivetolic acid.
Inventors:
DU DEYAO (CN)
WANG GAOYAN (CN)
ZHANG QIAN (CN)
ZONG ZHEN (CN)
LI MINGYUE (CN)
QIU YUEYUE (CN)
YIN JIN (CN)
ZHANG HAOQIAN (CN)
WANG GAOYAN (CN)
ZHANG QIAN (CN)
ZONG ZHEN (CN)
LI MINGYUE (CN)
QIU YUEYUE (CN)
YIN JIN (CN)
ZHANG HAOQIAN (CN)
Application Number:
PCT/CN2022/071331
Publication Date:
March 16, 2023
Filing Date:
January 11, 2022
Export Citation:
Assignee:
BEIJING BLUEPHA MICROBIOLOGY TECH CO LTD (CN)
SHENZHEN BLUEPHA BIOSCIENCES CO LTD (CN)
SHENZHEN BLUEPHA BIOSCIENCES CO LTD (CN)
International Classes:
C12N1/21; C12N15/53; C12N15/60; C12N15/70; C12R1/19
Domestic Patent References:
| WO2019210404A1 | 2019-11-07 | |||
| WO2020160289A1 | 2020-08-06 | |||
| WO2021081648A1 | 2021-05-06 | |||
| WO2020102541A1 | 2020-05-22 |
Foreign References:
| CN113502255A | 2021-10-15 | |||
| US20190382813A1 | 2019-12-19 |
Other References:
ZAIGAO TAN, ET AL.: "Synthetic Pathway for the Production of Olivetolic Acid in Escherichia coli", ACS SYNTHETIC BIOLOGY, AMERICAN CHEMICAL SOCIETY, WASHINGTON DC ,USA, vol. 7, no. 8, 17 August 2018 (2018-08-17), Washington DC ,USA , pages 1886 - 1896, XP055652181, ISSN: 2161-5063, DOI: 10.1021/acssynbio.8b00075
Attorney, Agent or Firm:
KING & WOOD MALLESONS (CN)
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