Title:
ENHANCED SYNTHETIC T-CELL RECEPTOR AND ANTIGEN RECEPTOR
Document Type and Number:
WIPO Patent Application WO/2021/238903
Kind Code:
A1
Abstract:
Provided is a CD19 and CD20-targeting enhanced synthetic T-cell receptor and antigen receptor (STAR), a T cell containing the STAR, and use thereof.
Inventors:
RUI WEI (CN)
WANG JIASHENG (CN)
LEI LEI (CN)
YU LI (CN)
ZHAO XUEQIANG (CN)
LIN XIN (CN)
WANG JIASHENG (CN)
LEI LEI (CN)
YU LI (CN)
ZHAO XUEQIANG (CN)
LIN XIN (CN)
Application Number:
PCT/CN2021/095733
Publication Date:
December 02, 2021
Filing Date:
May 25, 2021
Export Citation:
Assignee:
CHINA IMMUNOTECH BEIJING BIOTECHNOLOGY CO LTD (CN)
UNIV TSINGHUA (CN)
UNIV TSINGHUA (CN)
International Classes:
C07K19/00; A61K35/17; A61K39/00; A61P35/00; C12N5/10
Foreign References:
| CN110741016A | 2020-01-31 | |||
| CN110818802A | 2020-02-21 | |||
| CN107614519A | 2018-01-19 | |||
| CN110662547A | 2020-01-07 | |||
| CN201810898720A | 2018-08-08 |
Other References:
LIU YUE, LIU GUANGNA, WANG JIASHENG, ZHENG ZHE-YU, JIA LEMEI, RUI WEI, HUANG DAOSHENG, ZHOU ZHI-XIAO, ZHOU LIQUN, WU XIN, LIN SONG: "Chimeric STAR receptors using TCR machinery mediate robust responses against solid tumors", SCIENCE TRANSLATION MEDICINE, vol. 13, no. 586, 24 March 2021 (2021-03-24), pages 1 - 16, XP055872041, ISSN: 1946-6234, DOI: 10.1126/scitranslmed.abb5191
BENJAMIN Y JIN; TRACY E CAMPBELL; LINDSEY M DRAPER; SANJA STEVANOVIĆ; BIANCA WEISSBRICH; ZHIYA YU; NICHOLAS P RESTIFO; STEVEN A RO: "Engineered T cells targeting E7 mediate regression of human papillomavirus cancers in a murine model", JCI INSIGHT, vol. 3, no. 8, 19 April 2018 (2018-04-19), pages 1 - 12, XP055599336, ISSN: 2379-3708, DOI: 10.1172/jci.insight.99488
HAGA-FRIEDMAN A; HOROVITZ-FRIED M; COHEN C J: "Incorporation of Transmembrane Hydrophobic Mutations in the TCR Enhance Its Surface Expression and T Cell Functional Avidity", THE JOURNAL OF IMMUNOLOGY, vol. 188, no. 11, 1 June 2012 (2012-06-01), pages 5538 - 5546, XP055201584, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1103020
SMITA S CHANDRAN; CHRISTOPHER A KLEBANOFF: "T cell receptor-based cancer immunotherapy: Emerging efficacy and pathways of resistance", IMMUNOLOGICAL REVIEWS, vol. 290, no. 1, 31 July 2019 (2019-07-31), pages 127 - 147, XP055673502, ISSN: 0105-2896, DOI: 10.1111/imr.12772
YIYANG XU; ZHIYUAN YANG; LUCAS H HORAN; PENGBO ZHANG; LIANXING LIU; BRYAN ZIMDAHL; SHON GREEN; JINGWEI LU; JAVIER F MORALES; DAVID: "A novel antibody-TCR (AbTCR) platform combines Fab-based antigen recognition with gamma/delta-TCR signaling to facilitate T-cell cytotoxicity with low cytokine release", CELL DISCOVERY, vol. 4, no. 1, 62, 1 December 2018 (2018-12-01), pages 1 - 13, XP055583500, DOI: 10.1038/s41421-018-0066-6
LIJUN ZHAO; YU J CAO: "Engineered T Cell Therapy for Cancer in the Clinic", FRONTIERS IN IMMUNOLOGY, vol. 10, 2250, 1 January 2019 (2019-01-01), pages 1 - 20, XP055674522, DOI: 10.3389/fimmu.2019.02250
SAMBROOK ET AL., MOLECULAR CLONING: A LABORATORY MANUAL
LEWIN, GENES VIII
ROITT ET AL., IMMUNOLOGY
BENJAMIN Y JIN; TRACY E CAMPBELL; LINDSEY M DRAPER; SANJA STEVANOVIĆ; BIANCA WEISSBRICH; ZHIYA YU; NICHOLAS P RESTIFO; STEVEN A RO: "Engineered T cells targeting E7 mediate regression of human papillomavirus cancers in a murine model", JCI INSIGHT, vol. 3, no. 8, 19 April 2018 (2018-04-19), pages 1 - 12, XP055599336, ISSN: 2379-3708, DOI: 10.1172/jci.insight.99488
HAGA-FRIEDMAN A; HOROVITZ-FRIED M; COHEN C J: "Incorporation of Transmembrane Hydrophobic Mutations in the TCR Enhance Its Surface Expression and T Cell Functional Avidity", THE JOURNAL OF IMMUNOLOGY, vol. 188, no. 11, 1 June 2012 (2012-06-01), pages 5538 - 5546, XP055201584, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1103020
SMITA S CHANDRAN; CHRISTOPHER A KLEBANOFF: "T cell receptor-based cancer immunotherapy: Emerging efficacy and pathways of resistance", IMMUNOLOGICAL REVIEWS, vol. 290, no. 1, 31 July 2019 (2019-07-31), pages 127 - 147, XP055673502, ISSN: 0105-2896, DOI: 10.1111/imr.12772
YIYANG XU; ZHIYUAN YANG; LUCAS H HORAN; PENGBO ZHANG; LIANXING LIU; BRYAN ZIMDAHL; SHON GREEN; JINGWEI LU; JAVIER F MORALES; DAVID: "A novel antibody-TCR (AbTCR) platform combines Fab-based antigen recognition with gamma/delta-TCR signaling to facilitate T-cell cytotoxicity with low cytokine release", CELL DISCOVERY, vol. 4, no. 1, 62, 1 December 2018 (2018-12-01), pages 1 - 13, XP055583500, DOI: 10.1038/s41421-018-0066-6
LIJUN ZHAO; YU J CAO: "Engineered T Cell Therapy for Cancer in the Clinic", FRONTIERS IN IMMUNOLOGY, vol. 10, 2250, 1 January 2019 (2019-01-01), pages 1 - 20, XP055674522, DOI: 10.3389/fimmu.2019.02250
SAMBROOK ET AL., MOLECULAR CLONING: A LABORATORY MANUAL
LEWIN, GENES VIII
ROITT ET AL., IMMUNOLOGY
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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