Title:
FC-CD80 FUSION PROTEIN AND CONJUGATE THEREOF, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/238904
Kind Code:
A1
Abstract:
The present invention provides a Fc-CD80 fusion protein that is a fusion protein with a CD80 extracellular domain (ECD) attached to a terminus C of an immunoglobulin Fc domain. The Fc-CD80 fusion protein can be used for preparing a conjugate. The conjugate comprises the Fc-CD80 fusion protein serving as a first component, and comprises a second component containing a second effector molecule. The second component is located at a terminus N of the first component. The present invention also provides a conjugate of an Fc-CD80 fusion protein, a pharmaceutical composition comprising the Fc-CD80 fusion protein and/or the conjugate, and use of the Fc-CD80 fusion protein, the conjugate or the pharmaceutical composition in treating or preventing cancerous diseases in individuals.
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Inventors:
HU PINLIANG (CN)
ZOU JING (CN)
HONG WEIDONG (CN)
HE YUN (CN)
SONG LINGYUN (CN)
YANG WENDI (CN)
ZOU JING (CN)
HONG WEIDONG (CN)
HE YUN (CN)
SONG LINGYUN (CN)
YANG WENDI (CN)
Application Number:
PCT/CN2021/095750
Publication Date:
December 02, 2021
Filing Date:
May 25, 2021
Export Citation:
Assignee:
BEIJING BEYOND BIOTECHNOLOGY CO LTD (CN)
International Classes:
C07K19/00; A61K38/17; A61K39/395; A61P35/00
Domestic Patent References:
| WO2020060122A1 | 2020-03-26 |
Foreign References:
| CN109721657A | 2019-05-07 | |||
| CN111423512A | 2020-07-17 | |||
| JP2005206478A | 2005-08-04 | |||
| US20130149305A1 | 2013-06-13 | |||
| CN110546509A | 2019-12-06 |
Attorney, Agent or Firm:
ZHONGZI LAW OFFICE (CN)
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