Title:
ENZYMATIC PROCESS FOR THE MANUFACTURE OF L-ASCORBIC ACID AND D-ERYTHORBIC ACID
Document Type and Number:
WIPO Patent Application WO2003040381
Kind Code:
A3
Abstract:
A process for producing L-ascorbic acid from 2-keto-L-gulonic acid or D-erythorbic acid from 2-keto-D-gluconic acid by contacting 2-keto-L-gulonic acid or 2-keto-D-gluconic acid, respectively, with an enzym having alpha -amylase activity in solution. The solvent for this reaction can be water, an aqueous alcohol, an organic solvent or a mixture thereof. In each case, the starting material can be in the form of the free acid, the sodium salt, or the calcium salt.
Inventors:
HOSHINO TATSUO (JP)
KIYASU TATSUYA (JP)
SHINJOH MASAKO (JP)
KIYASU TATSUYA (JP)
SHINJOH MASAKO (JP)
Application Number:
PCT/EP2002/012157
Publication Date:
July 31, 2003
Filing Date:
October 31, 2002
Export Citation:
Assignee:
ROCHE VITAMINS AG (CH)
HOSHINO TATSUO (JP)
KIYASU TATSUYA (JP)
SHINJOH MASAKO (JP)
HOSHINO TATSUO (JP)
KIYASU TATSUYA (JP)
SHINJOH MASAKO (JP)
International Classes:
C12N9/26; C12P17/04; (IPC1-7): C12P17/04; C12N9/26
Foreign References:
| US5817490A | 1998-10-06 | |||
| US6146860A | 2000-11-14 |
Other References:
DECLERCK N ET AL: "HYPERTHERMOSTABLE MUTANTS OF BACILLUS LICHENIFORMIS ALPHA-AMYLASE: MULTIPLE AMINO ACID REPLACEMENTS AND MOLECULAR MODELLING", PROTEIN ENGINEERING, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 8, no. 10, 1995, pages 1029 - 1037, XP002934365, ISSN: 0269-2139
YUUKI T ET AL: "COMPLETE NUCLEOTIDE SEQUENCE OF A GENE CODING FOR HEAT- AND PH-STABLE ALPHA-AMYLASE OF BACILLUS LICHENIFORMIS: COMPARISON OF THE AMINO ACID SEQUENCES OF THREE BACTERIAL LIQUIFYING ALPHA-AMYLASES DEDUCED FROM THE DNA SEQUENCES", JOURNAL OF BIOCHEMISTRY, JAPANESE BIOCHEMICAL SOCIETY, TOKYO, JP, vol. 98, no. 5, 1985, pages 1147 - 1156, XP002017641, ISSN: 0021-924X
TAKASAKI Y ET AL: "ACID-STABLE AND THERMOSTABLE ALPHA-AMYLASE FROM BACILLUS LICHENIFORMIS ALPHA", JOURNAL OF FERMENTATION AND BIOENGINEERING, SOCIETY OF FERMENTATION TECHNOLOGY, JP, vol. 77, no. 1, 1994, pages 94 - 96, XP008005412, ISSN: 0922-338X
YUUKI T ET AL: "COMPLETE NUCLEOTIDE SEQUENCE OF A GENE CODING FOR HEAT- AND PH-STABLE ALPHA-AMYLASE OF BACILLUS LICHENIFORMIS: COMPARISON OF THE AMINO ACID SEQUENCES OF THREE BACTERIAL LIQUIFYING ALPHA-AMYLASES DEDUCED FROM THE DNA SEQUENCES", JOURNAL OF BIOCHEMISTRY, JAPANESE BIOCHEMICAL SOCIETY, TOKYO, JP, vol. 98, no. 5, 1985, pages 1147 - 1156, XP002017641, ISSN: 0021-924X
TAKASAKI Y ET AL: "ACID-STABLE AND THERMOSTABLE ALPHA-AMYLASE FROM BACILLUS LICHENIFORMIS ALPHA", JOURNAL OF FERMENTATION AND BIOENGINEERING, SOCIETY OF FERMENTATION TECHNOLOGY, JP, vol. 77, no. 1, 1994, pages 94 - 96, XP008005412, ISSN: 0922-338X
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