Title:
ENZYMATIC PRODUCTION OF ACYL FLAVONOID DERIVATIVES
Document Type and Number:
WIPO Patent Application WO2004050889
Kind Code:
A3
Abstract:
Disclosed is a method for the enzymatic synthesis of flavonoid esters and flavonoid derivatives, according to which a) a reaction medium containing an organic solvent, a glycosylated flavonoid or aglycone flavonoid, an acyl group donor, and an enzymatic catalyst is produced, b) additional quantities of flavonoid and/or acyl donor are optionally added during the reaction, and c) the obtained esters are purified by eliminating enzymatic particles and the solvent. The inventive method is characterized by the fact that the concentration of water and/or alcohol which are formed during the reaction is controlled so as to be maintained below 150 mM.
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Inventors:
GHOUL MOHAMED (FR)
ENGASSER JEAN-MARC (FR)
MOUSSOU PHILIPPE (FR)
PAULY GILLES (FR)
ARDHAOUI MELIKA (FR)
FALCIMAIGNE AUDE (FR)
ENGASSER JEAN-MARC (FR)
MOUSSOU PHILIPPE (FR)
PAULY GILLES (FR)
ARDHAOUI MELIKA (FR)
FALCIMAIGNE AUDE (FR)
Application Number:
PCT/EP2003/013143
Publication Date:
August 12, 2004
Filing Date:
November 22, 2003
Export Citation:
Assignee:
COGNIS FRANCE SA (FR)
GHOUL MOHAMED (FR)
ENGASSER JEAN-MARC (FR)
MOUSSOU PHILIPPE (FR)
PAULY GILLES (FR)
ARDHAOUI MELIKA (FR)
FALCIMAIGNE AUDE (FR)
GHOUL MOHAMED (FR)
ENGASSER JEAN-MARC (FR)
MOUSSOU PHILIPPE (FR)
PAULY GILLES (FR)
ARDHAOUI MELIKA (FR)
FALCIMAIGNE AUDE (FR)
International Classes:
C12P7/62; C12P17/06; (IPC1-7): C12P7/62
Domestic Patent References:
| WO2001079245A1 | 2001-10-25 |
Foreign References:
| EP0618203A1 | 1994-10-05 |
Other References:
KONTOGIANNI ATHINA ET AL: "Regioselective acylation of flavonoids catalyzed by lipase in low toxicity media", EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY, vol. 103, no. 10, October 2001 (2001-10-01), pages 655 - 660, XP002278630, ISSN: 1438-7697
DANIELI B ET AL: "CHEMO-ENZYMATIC SYNTHESIS OF 6-O-(3-ARYLPROP-2-ENOYL) DERIVATIVES OF THE FLAVONOL GLUCOSIDE ISOQUERCITRIN", HELVETICA CHIMICA ACTA, VERLAG HELVETICA CHIMICA ACTA. BASEL, CH, vol. 76, no. 8, 1993, pages 2981 - 2991, XP002027015, ISSN: 0018-019X
DANIELI B ET AL: "CHEMO-ENZYMATIC SYNTHESIS OF 6-O-(3-ARYLPROP-2-ENOYL) DERIVATIVES OF THE FLAVONOL GLUCOSIDE ISOQUERCITRIN", HELVETICA CHIMICA ACTA, VERLAG HELVETICA CHIMICA ACTA. BASEL, CH, vol. 76, no. 8, 1993, pages 2981 - 2991, XP002027015, ISSN: 0018-019X
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