Title:
EPIGENETIC METHODS AND NUCLEIC ACIDS FOR THE DETECTION OF LUNG CELL PROLIFERATIVE DISORDERS
Document Type and Number:
WIPO Patent Application WO2006034879
Kind Code:
A3
Abstract:
The invention provides methods, nucleic acids and kits for detecting, classifying and/or distinguishing between or among lung cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
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Inventors:
PLUM ACHIM (DE)
RUJAN TAMAS (DE)
MAIER SABINE (DE)
LESCHE RALF (DE)
GRAHAM ALEXANDER (GB)
SOUTH MARIE (GB)
BAILEY IACONA RENNEE (US)
RUJAN TAMAS (DE)
MAIER SABINE (DE)
LESCHE RALF (DE)
GRAHAM ALEXANDER (GB)
SOUTH MARIE (GB)
BAILEY IACONA RENNEE (US)
Application Number:
PCT/EP2005/010611
Publication Date:
August 03, 2006
Filing Date:
September 30, 2005
Export Citation:
Assignee:
EPIGENOMICS AG (DE)
PLUM ACHIM (DE)
RUJAN TAMAS (DE)
MAIER SABINE (DE)
LESCHE RALF (DE)
GRAHAM ALEXANDER (GB)
SOUTH MARIE (GB)
BAILEY IACONA RENNEE (US)
PLUM ACHIM (DE)
RUJAN TAMAS (DE)
MAIER SABINE (DE)
LESCHE RALF (DE)
GRAHAM ALEXANDER (GB)
SOUTH MARIE (GB)
BAILEY IACONA RENNEE (US)
International Classes:
C12Q1/68
Domestic Patent References:
| WO2002000926A2 | 2002-01-03 | |||
| WO2003052135A2 | 2003-06-26 | |||
| WO2004071572A2 | 2004-08-26 | |||
| WO2004055022A1 | 2004-07-01 |
Other References:
LIN XIONGBIN ET AL: "Overexpression of phosphatidylinositol 3-kinase in human lung cancer", LANGENBECK'S ARCHIVES OF SURGERY, vol. 386, no. 4, July 2001 (2001-07-01), pages 293 - 301, XP002359632, ISSN: 1435-2443
ESTELLER M ET AL: "Detection of aberrant promotor hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 59, 1 January 1999 (1999-01-01), pages 67 - 70, XP002959643, ISSN: 0008-5472
TOYOOKA SHINICHI ET AL: "DNA methylation profiles of lung tumors", MOLECULAR CANCER THERAPEUTICS, AMERICAN ASSOCIATION OF CANCER RESEARCH, US, vol. 1, no. 1, November 2001 (2001-11-01), pages 61 - 67, XP002251519, ISSN: 1535-7163
TSOU J A ET AL: "DNA methylation analysis: A powerful new tool for lung cancer diagnosis", ONCOGENE, BASINGSTOKE, HANTS, GB, vol. 21, no. 35 Review Issue 3, 2002, pages 5450 - 5461, XP002251522, ISSN: 0950-9232
KIM RACHEL ET AL: "Genome-based identification of cancer genes by proviral tagging in mouse retrovirus-induced T-cell lymphomas.", JOURNAL OF VIROLOGY, vol. 77, no. 3, February 2003 (2003-02-01), pages 2056 - 2062, XP002359633, ISSN: 0022-538X
HIJAZI M M ET AL: "NRG-3 IN HUMAN BREAST CANCERS: ACTIVATION OF MULTIPLE ERBB FAMILY PROTEINS", INTERNATIONAL JOURNAL OF ONCOLOGY, EDITORIAL ACADEMY OF THE INTERNATIONAL JOURNAL OF ONCOLOGY,, GR, vol. 13, no. 5, 1998, pages 1061 - 1067, XP009053200, ISSN: 1019-6439
WATSON J E VIVIENNE ET AL: "Integration of high-resolution array comparative genomic hybridization analysis of chromosome 16q with expression array data refines common regions of loss at16q23-qter and identifies underlying candidate tumor suppressor genes in prostate cancer", ONCOGENE, vol. 23, no. 19, 22 April 2004 (2004-04-22), pages 3487 - 3494, XP002359634, ISSN: 0950-9232
ESTELLER M ET AL: "Detection of aberrant promotor hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 59, 1 January 1999 (1999-01-01), pages 67 - 70, XP002959643, ISSN: 0008-5472
TOYOOKA SHINICHI ET AL: "DNA methylation profiles of lung tumors", MOLECULAR CANCER THERAPEUTICS, AMERICAN ASSOCIATION OF CANCER RESEARCH, US, vol. 1, no. 1, November 2001 (2001-11-01), pages 61 - 67, XP002251519, ISSN: 1535-7163
TSOU J A ET AL: "DNA methylation analysis: A powerful new tool for lung cancer diagnosis", ONCOGENE, BASINGSTOKE, HANTS, GB, vol. 21, no. 35 Review Issue 3, 2002, pages 5450 - 5461, XP002251522, ISSN: 0950-9232
KIM RACHEL ET AL: "Genome-based identification of cancer genes by proviral tagging in mouse retrovirus-induced T-cell lymphomas.", JOURNAL OF VIROLOGY, vol. 77, no. 3, February 2003 (2003-02-01), pages 2056 - 2062, XP002359633, ISSN: 0022-538X
HIJAZI M M ET AL: "NRG-3 IN HUMAN BREAST CANCERS: ACTIVATION OF MULTIPLE ERBB FAMILY PROTEINS", INTERNATIONAL JOURNAL OF ONCOLOGY, EDITORIAL ACADEMY OF THE INTERNATIONAL JOURNAL OF ONCOLOGY,, GR, vol. 13, no. 5, 1998, pages 1061 - 1067, XP009053200, ISSN: 1019-6439
WATSON J E VIVIENNE ET AL: "Integration of high-resolution array comparative genomic hybridization analysis of chromosome 16q with expression array data refines common regions of loss at16q23-qter and identifies underlying candidate tumor suppressor genes in prostate cancer", ONCOGENE, vol. 23, no. 19, 22 April 2004 (2004-04-22), pages 3487 - 3494, XP002359634, ISSN: 0950-9232
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