AN ERYTHROPOIETIN MIMETIC PEPTIDE DERIVATIVES AND ITS PHARMACEUTICAL SALT, THE PREPARATION AND USES THEREOF

Title:

AN ERYTHROPOIETIN MIMETIC PEPTIDE DERIVATIVES AND ITS PHARMACEUTICAL SALT, THE PREPARATION AND USES THEREOF

Document Type and Number:

WIPO Patent Application WO/2009/079910

Kind Code:

A1

Abstract:

What is provided is an erythropoietin mimetic peptide derivatives defined as formula (I) and its pharmaceutical salt, the preparation thereof, wherein R1, R2, R3, R4, R5, n1, n2 are defined as described in description. A composition comprising of an erythropoietin mimetic peptide derivatives defined as formula (I) and its pharmaceutical salt. The uses of the derivatives and its pharmaceutical salt, as well as the uses of the composition described above in treatment of diseases characterized by a deficiency of erythropoietin or a low or defective red blood cell population. R1- R2-(CH2)n1-R3-(CH2)n2-R4-R5 (I)

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Inventors:

LUE AIFENG (CN)
SUN CHANGAN (CN)
JIANG TAO (CN)
WU WENTAO (CN)
WANG YALI (CN)

Application Number:

PCT/CN2008/001909

Publication Date:

July 02, 2009

Filing Date:

November 24, 2008

Export Citation:

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Assignee:

JIANGSU HANSEN PHARMACEUTICAL (CN)
LUE AIFENG (CN)
SUN CHANGAN (CN)
JIANG TAO (CN)
WU WENTAO (CN)
WANG YALI (CN)

International Classes:

C07K17/08; A61K47/48; A61P7/06; C07K14/505

Domestic Patent References:

WO2006062685A2	2006-06-15
WO2006060148A2	2006-06-08
WO1990008822A1	1990-08-09

Foreign References:

CN1820024A	2006-08-16
CN1823087A	2006-08-23
CN1823088A	2006-08-23
CN1680449A	2005-10-12
CN1226176A	1999-08-18
CN1338463A	2002-03-06

Other References:

JOHNSON D L ET AL.: "Amino-terminal dimerization of an erythropoietin mimetic peptide results in increased erythropoietic activity.", vol. 4, no. 12, 1997, pages 939 - 950, XP026916286, DOI: doi:10.1016/S1074-5521(97)90302-1
See also references of EP 2233504A4
SAWYER ET AL., PROC. NATL. ACAD. SCI.USA, vol. 84, 1987, pages 3690 - 3694

Attorney, Agent or Firm:

GE CHENG & CO., LTD. (Tower E3 The Towers, Oriental Plaza,No.1, East Chang An Avenue, Dongcheng District, Beijing 8, CN)

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