Title:
ESTRADIOL METABOLITES FOR THE TREATMENT OF PULMONARY HYPERTENSION
Document Type and Number:
WIPO Patent Application WO2004073643
Kind Code:
A3
Abstract:
Methods are provided for the treatment of pulmonary hypertension and other conditions associated therewith. In particular, the methods include treatment of pulmonary hypertension with estradiol metabolite or estradiol metabolite associated with biodegradable microparticles or nanoparticles alone or in combination with another therapeutic agent. Preferred estradiol metabolites include 2-methoxyestradiol, 4-methoxyestradiol, 2-hydroxyestradiol, and 4-hydroxyestradiol, and/or to synthetic derivatives and analogues thereof or prodrugs thereof. The compositions may also be in the form of a controlled release formulation.
Inventors:
TOFOVIC STEVAN P
JACKSON EDWIN K
JACKSON EDWIN K
Application Number:
PCT/US2004/004841
Publication Date:
March 24, 2005
Filing Date:
February 20, 2004
Export Citation:
Assignee:
UNIV PITTSBURGH (US)
International Classes:
A61K9/00; A61K31/00; A61K31/56; A61K31/565; A61K47/10; (IPC1-7): A61K31/56; A61K31/58
Foreign References:
| US20010056068A1 | 2001-12-27 |
Other References:
XIAO ET AL.: "Effects of Estradiol and Its Metabolites on Glomerular Endothelial Nitric Oxide Synthesis and Mesangial Cell Growth", HYPERTENSION, vol. 37, no. PART 2, 2001, pages 645 - 650, XP002978795
Download PDF: