Title:
ETHANE-SULFONATE SALT OF QUINOLINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2018/139527
Kind Code:
A1
Abstract:
The present invention relates to an ethane-sulfonate salt of N-{5-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-pyridinyl}-2,5-dioxo-1-phenyl-1,2,5,6,7,8-hexahydro-3-quinolinecarboxamide, which has an Axl-inhibiting activity and is useful as a prophylactic and/or therapeutic agent for immune diseases, cancer and the like, a crystal thereof, and a pharmaceutical composition thereof.
Inventors:
NEKADO TAKAHIRO (JP)
KIJIMA HIDEOMI (JP)
ONO SHIZUKA (JP)
NISHIYAMA TOSHIHIKO (JP)
KIJIMA HIDEOMI (JP)
ONO SHIZUKA (JP)
NISHIYAMA TOSHIHIKO (JP)
Application Number:
PCT/JP2018/002250
Publication Date:
August 02, 2018
Filing Date:
January 25, 2018
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
International Classes:
C07D401/14; A61K31/4709; A61P9/00; A61P13/12; A61P35/00; A61P35/02; A61P37/02; A61P43/00
Domestic Patent References:
| WO2015012298A1 | 2015-01-29 | |||
| WO2012028332A1 | 2012-03-08 | |||
| WO2013074633A1 | 2013-05-23 | |||
| WO2012011548A1 | 2012-01-26 | |||
| WO2006116713A1 | 2006-11-02 | |||
| WO2015012298A1 | 2015-01-29 |
Foreign References:
| JP2003519698A | 2003-06-24 |
Other References:
BERGE, S. M. ET AL.: "Pharmaceutical salts", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 66, no. 1, 1977, pages 1 - 19, XP002675560
ANONYMOUS: "API form screening and selection in drug discovery stage", PHARM STAGE, vol. 6, no. 10, 2007, pages 20 - 25, XP008145548, ISSN: 1346-3918
BYRN, S. ET AL.: "Pharmaceutical Solids: A Strategic Approach to Regulatory Considerations", PHARMACEUTICAL RESEARCH, vol. 12, no. 7, 1995, pages 945 - 954, XP055531015
CLINICAL SCIENCE, vol. 122, 2012, pages 361 - 368
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 107, no. 3, 2010, pages 1124 - 1129
BLOOD, vol. 121, 2013, pages 2064 - 2073
See also references of EP 3575293A4
ANONYMOUS: "API form screening and selection in drug discovery stage", PHARM STAGE, vol. 6, no. 10, 2007, pages 20 - 25, XP008145548, ISSN: 1346-3918
BYRN, S. ET AL.: "Pharmaceutical Solids: A Strategic Approach to Regulatory Considerations", PHARMACEUTICAL RESEARCH, vol. 12, no. 7, 1995, pages 945 - 954, XP055531015
CLINICAL SCIENCE, vol. 122, 2012, pages 361 - 368
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 107, no. 3, 2010, pages 1124 - 1129
BLOOD, vol. 121, 2013, pages 2064 - 2073
See also references of EP 3575293A4
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
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