Title:
EXAMINATION METHOD AND EXAMINATION KIT FOR EOSINOPHILIC GASTROINTESTINAL DISEASE OR FOOD-PROTEIN INDUCED ENTEROPATHY
Document Type and Number:
WIPO Patent Application WO/2018/043715
Kind Code:
A1
Abstract:
Provided is a new method for examining eosinophilic gastrointestinal diseases or food-protein induced enteropathies. In other words, the present invention relates to a method for examining eosinophilic gastrointestinal diseases or food-protein induced enteropathies, the method including a measuring step for measuring the expression level of at least one of TSLP gene, IL-33 gene, CCL7 gene, and CCL21 gene in a sample collected from a living human subject or measuring the amount of at least one of TSLP protein, IL-33 protein, CCL7 protein, and CCL21 protein in said sample.
Inventors:
NOMURA ICHIRO (JP)
MATSUMOTO KENJI (JP)
MATSUMOTO KENJI (JP)
Application Number:
PCT/JP2017/031636
Publication Date:
March 08, 2018
Filing Date:
September 01, 2017
Export Citation:
Assignee:
NAT CT CHILD HEALTH & DEV (JP)
International Classes:
C12N15/09; C12Q1/68; G01N33/50; G01N33/53; G01N33/68
Domestic Patent References:
| WO2014059178A1 | 2014-04-17 | |||
| WO2015006571A1 | 2015-01-15 |
Other References:
HOLM, N. A. ET AL.: "Increased nuclear localization of interleukin 33 in eosinophilic esophagitis", GASTROENTEROLOGY, vol. 140, no. 5, 2011, pages S242, XP055472260
KNIPPING, K. ET AL.: "Serum immunoglobulin free light chain levels are higher in girls than boys during eosinophilic oesophagitis .", ACTA PAEDIATRICA, vol. 103, no. 7, 2014, pages 766 - 774, XP055472261
SHODA, T. ET AL.: "Sera of patients with infantile eosinophilic gastroenteritis showed a specific increase in both thymic stromal lymphopoietin and IL -33 levels.", J. ALLERGY CLIN.IMMUNOL., vol. 138, no. 1, 2 March 2016 (2016-03-02), pages 299 - 303, XP029627846, DOI: doi:10.1016/j.jaci.2015.11.042
KNIPPING, K. ET AL.: "Serum immunoglobulin free light chain levels are higher in girls than boys during eosinophilic oesophagitis .", ACTA PAEDIATRICA, vol. 103, no. 7, 2014, pages 766 - 774, XP055472261
SHODA, T. ET AL.: "Sera of patients with infantile eosinophilic gastroenteritis showed a specific increase in both thymic stromal lymphopoietin and IL -33 levels.", J. ALLERGY CLIN.IMMUNOL., vol. 138, no. 1, 2 March 2016 (2016-03-02), pages 299 - 303, XP029627846, DOI: doi:10.1016/j.jaci.2015.11.042
Attorney, Agent or Firm:
HARAKENZO WORLD PATENT & TRADEMARK (JP)
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