Title:
EXHALED BIOMARKER FOR DIAGNOSIS AND PROGNOSIS OF PATIENT WITH IDIOPATHIC PULMONARY FIBROSIS
Document Type and Number:
WIPO Patent Application WO/2024/039205
Kind Code:
A1
Abstract:
The present invention relates to an exhaled biomarker for the diagnosis and prognosis of patients with idiopathic pulmonary fibrosis. Among volatile organic compounds in respiratory gas, an exhaled biomarker was screened. The biomarker according to the present invention is a compound specific to idiopathic pulmonary fibrosis and not only has excellent performance in distinguishing idiopathic pulmonary fibrosis patients from normal control groups and other interstitial lung disease groups, but also allows for non-invasive diagnosis, and thus can be applied to elderly patients and advantageously used as an exhaled biomarker for the diagnosis and prognosis of patients with idiopathic pulmonary fibrosis.
Inventors:
SONG JIN WOO (KR)
Application Number:
PCT/KR2023/012212
Publication Date:
February 22, 2024
Filing Date:
August 17, 2023
Export Citation:
Assignee:
UNIV ULSAN FOUND IND COOP (KR)
International Classes:
G01N33/497; G01N30/72
Domestic Patent References:
| WO2011054893A2 | 2011-05-12 |
Foreign References:
| KR20180066395A | 2018-06-19 | |||
| KR20150130408A | 2015-11-23 |
Other References:
LI MENG, REN HONGYAN, LIU LIFAN, LI WENTING, WANG ZIQI, ZHANG JINGJING, WANG XIAOLI, HU YIPING, ZANG KAIXUAN, AN YUNXIA, XU ZHIWEI: "Serum profiles of metabolomic and GDF-15 differentiate idiopathic pulmonary fibrosis from other interstital lung diseases: a preliminary study", BIORXIV, 22 March 2022 (2022-03-22), XP093140256, Retrieved from the Internet [retrieved on 20240312], DOI: 10.1101/2022.03.22.484740
E. MASTRIGT; J. C. JONGSTE; M. W. PIJNENBURG: "The analysis of volatile organic compounds in exhaled breath and biomarkers in exhaled breath condensate in children – clinical tools or scientific toys?", CLINICAL & EXPERIMENTAL ALLERGY, WILEY INTERSCIENCE, UK, vol. 45, no. 7, 17 June 2015 (2015-06-17), UK , pages 1170 - 1188, XP071888183, ISSN: 0954-7894, DOI: 10.1111/cea.12454
E. MASTRIGT; J. C. JONGSTE; M. W. PIJNENBURG: "The analysis of volatile organic compounds in exhaled breath and biomarkers in exhaled breath condensate in children – clinical tools or scientific toys?", CLINICAL & EXPERIMENTAL ALLERGY, WILEY INTERSCIENCE, UK, vol. 45, no. 7, 17 June 2015 (2015-06-17), UK , pages 1170 - 1188, XP071888183, ISSN: 0954-7894, DOI: 10.1111/cea.12454
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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