Title:
EXOSOME SECRETION INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2017/043370
Kind Code:
A1
Abstract:
An exosome secretion inhibitor comprising a substance that suppresses the expression of NAPG, HINT3 or GXYLT1 gene or a substance that suppresses the activity of NAPG, HINT3 or GXYLT1 protein. The exosome secretion inhibitor enables the suppression of exosome secretion and, as a result, enables the suppression of the proliferation and metastasis of cancer cells. Thus, the substance capable of suppressing the expression of the aforesaid gene or the activity of the aforesaid protein can be provided as an active ingredient of a medicinal composition, which is appropriately usable for cancer therapy or cancer metastasis suppression, and also as an anticancer drug having a novel function mechanism of specifically suppressing the expression of the aforesaid gene or the activity of the aforesaid protein.
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Inventors:
OCHIYA TAKAHIRO
YOSHIOKA YUSUKE
KOSAKA NOBUYOSHI
YOSHIOKA YUSUKE
KOSAKA NOBUYOSHI
Application Number:
PCT/JP2016/075324
Publication Date:
March 16, 2017
Filing Date:
August 30, 2016
Export Citation:
Assignee:
SHIONOGI & CO (JP)
THEORIA SCIENCE INC (JP)
THEORIA SCIENCE INC (JP)
International Classes:
A61K45/00; A61K31/7088; A61K31/7105; A61K48/00; A61P35/00; A61P43/00; C12N15/113; C12Q1/68; G01N33/15; G01N33/50
Domestic Patent References:
| WO2012069836A2 | 2012-05-31 |
Foreign References:
| JP2012125247A | 2012-07-05 | |||
| JP2013507987A | 2013-03-07 |
Other References:
HAN, K. ET AL.: "microRNA-194 suppresses osteosarcoma cell proliferation and metastasis in vitro and in vivo by targeting CDH2 and IGF1R", INT. J. ONCOLOGY, vol. 45, 2014, pages 1437 - 1449, XP055369547
MENG, Z. ET AL.: "miR-194 is a marker of hepatic epithelial cells and suppresses metastasis of liver cancer cells in mice", HEPATOLOGY, vol. 52, no. 6, December 2010 (2010-12-01), pages 2148 - 2157, XP055369558
KHELLA, HW. ET AL.: "miR-192, miR-194 and miR- 215: a convergent microRNA network suppressing tumor progression in renal cell carcinoma", CARCINOGENESIS, vol. 34, no. 10, 2013, pages 2231 - 2239, XP055369580
See also references of EP 3348278A4
MENG, Z. ET AL.: "miR-194 is a marker of hepatic epithelial cells and suppresses metastasis of liver cancer cells in mice", HEPATOLOGY, vol. 52, no. 6, December 2010 (2010-12-01), pages 2148 - 2157, XP055369558
KHELLA, HW. ET AL.: "miR-192, miR-194 and miR- 215: a convergent microRNA network suppressing tumor progression in renal cell carcinoma", CARCINOGENESIS, vol. 34, no. 10, 2013, pages 2231 - 2239, XP055369580
See also references of EP 3348278A4
Attorney, Agent or Firm:
HOSODA, Yoshinori (JP)
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