EXPRESSION POTENTIATOR FOR PROTEIN SYNTHESIS REGULATORY GENE

WIPO Patent Application WO/2002/036153

A1

By specifying the combination of human interferon a subtypes remarkably potentiating the expression of a protein synthesis regulatory gene, an expression potentiator for the above gene containing this combination as the active ingredient and use thereof are provided. Namely, an expression potentiator for a protein synthesis regulatory gene which contains as the active ingredients subtypes $g(a)2 and $g(a)8 of human interferon $g(a) and use of this potentiator involving medicines.

YANAI YOSHIAKI (JP)
SANO OSAMU (JP)
KURIMOTO MASASHI (JP)

PCT/JP2001/008390

May 10, 2002

September 26, 2001

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HAYASHIBARA BIOCHEM LAB (JP)
YANAI YOSHIAKI (JP)
SANO OSAMU (JP)
KURIMOTO MASASHI (JP)

C12N15/09; A61K38/21; A61P1/00; A61P1/04; A61P1/16; A61P7/00; A61P9/00; A61P17/00; A61P21/00; A61P25/00; A61P27/02; A61P29/00; A61P31/18; A61P35/02; A61P37/00; A61P37/08; A61P43/00; C12N5/07; C12N5/071; C12P21/02; (IPC1-7): A61K38/21; A61P43/00

YAMAOKA T. ET AL.: "Biologic and binding activities of IFN-alpha subtypes in ACHN human renal cell carcinoma cells and Daudi Burkitt's lymphoma cells", J. INTERFERON CYTOKINE RES., vol. 19, no. 12, 1999, pages 1343 - 1349, XP002907458
SCHILLER J.H. ET AL.: "Effects of combinations of interferon-beta ser and interferon-gamma on interferon-inducible proteins and on the cell cycle", J. BIOL. RESPONSE MODIF., vol. 9, no. 4, 1990, pages 368 - 377, XP002907459
See also references of EP 1329223A4

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