FARNESYL-PROTEIN TRANSFERASE INHIBITORS - INTERNAT PHYTOCHEMISTRY RES LA

Title:

FARNESYL-PROTEIN TRANSFERASE INHIBITORS

Document Type and Number:

WIPO Patent Application WO1999043314

Kind Code:

A9

Abstract:

Substantially pure preparations of phosphosesquiterpenes are described. The compounds inhibit farnesyl-protein transferase activity and are useful for the treatment of cancer. Methods for inhibiting farnesyl-protein transferase activity are also described.

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Inventors:

SHAIKENOV TATTYM E
ADEKENOV SERGAZY M

Application Number:

PCT/US1999/004124

Publication Date:

March 01, 2001

Filing Date:

February 25, 1999

Export Citation:

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Assignee:

INTERNAT PHYTOCHEMISTRY RES LA (US)

International Classes:

C07D307/93; A61K31/28; A61K31/34; A61K31/343; A61K31/35; A61K31/365; A61K31/475; A61K31/505; A61K31/5377; A61K31/56; A61K31/66; A61K31/661; A61K31/6615; A61K31/675; A61K31/70; A61K33/24; A61K45/06; A61P35/00; A61P43/00; C07D303/38; C07D307/935; C07D493/04; C07D493/10; C07D493/14; C07D493/20; C07F9/09; C07F9/117; C07F9/655; (IPC1-7): A61K31/34; A61K31/66; C07C53/136; C07D307/93; C07D407/02

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