FILAGGRIN PRODUCTION PROMOTER, THERAPEUTIC AGENT FOR DISEASES ASSOCIATED WITH REDUCTION IN PRODUCTION OF FILAGGRIN, AND METHOD FOR SCREENING FOR SAID THERAPEUTIC AGENT

WIPO Patent Application WO/2014/017319

A1

Provided is a substance having a highly effective filaggrin production promoting activity. Also provided is a therapeutic drug useful for the treatment of skin diseases associated with the reduction in the production of filaggrin, particularly atopic dermatitis. The search for filaggrin production promoters has been made extensively. As a result, it is found that (A) an N-quinolylbenzamide derivative (compound 1), (B) ivermectin (compound 2) or (C) a phenylalanine amide derivative (compound 3) can promote the production of filaggrin in the skin and can improve the water-retaining ability or the barrier function of a horny cell layer. The present invention relates to a filaggrin production promoter characterized by containing a specific N-quinolylbenzamide derivative or a pharmaceutically acceptable salt thereof as an active ingredient.

JPWO2005011637	Dispersed formulation at the time of use
WO/2003/048140	AZOLE COMPOUND AND MEDICINAL USE THEREOF
JP2010500376	Glucocorticoid receptor, AP-1, and / or NF-κB activity regulator, and its use

KABASHIMA KENJI (JP)
OTSUKA ATSUSHI (JP)
EGAWA GYOHEI (JP)
DOI HIROMI (JP)
MAEKAWA AKIKO (JP)
NARUMIYA SHUH (JP)

PCT/JP2013/069163

January 30, 2014

July 12, 2013

Click for automatic bibliography generation  

UNIV KYOTO (JP)
ASTELLAS PHARMA INC (JP)

A61K31/4439; A61K45/00; A61K31/47; A61K31/7048; A61P17/00; A61P37/08; C12Q1/68; G01N33/15; G01N33/50; C07K14/705; C12N15/09

WO2002074341A1	2002-09-26
WO2010093849A2	2010-08-19
WO2010093849A2	2010-08-19
WO2002074341A1	2002-09-26

JP2012513387A	2012-06-14
JPH11335355A	1999-12-07
EP0001689B1	1984-03-21
JP2009256269A	2009-11-05
JP2003146886A	2003-05-21
JP2006241095A	2006-09-14
JP2010090037A	2010-04-22
JP2004175687A	2004-06-24
JPH0313989B2	1991-02-25
JPH11335355A	1999-12-07
EP0001689B1	1984-03-21
US20100004200A1	2010-01-07

E.MORITA ET AL.: "FUR MITES INDUCE DERMATITIS ASSOCIATED WITH IGE HYPERPRODUCTION IN AN INBRED STRAIN OF MICE, NC/KUJ", JOURNAL OF DERMATOLOGICAL SCIENCE, vol. 19, 1999, pages 37 - 43, XP027362682
"Karthikeyan, Kaliaperumal, Dr.", ARCHIVES OF DISEASE IN CHILDHOOD: EDUCATION AND PRACTICE EDITION, vol. 92, no. 3, June 2007 (2007-06-01), pages EP65 - EP69, XP008176147
S.YAN ET AL.: "ANTI-INFLAMMATORY EFFECTS OF IVERMECTIN IN MOUSE MODEL OF ALLERGIC ASTHMA", INFLAMM. RES., vol. 60, no. 6, June 2011 (2011-06-01), pages 589 - 596, XP019903961
J. INVEST. DERMATOL., vol. 103, no. 5, 1994, pages 731 - 740
J. CELL SCIENCE, vol. 122, no. 9, 2009, pages 1285 - 1294
NATURE GENETICS, vol. 38, 2006, pages 337 - 342
NATURE GENETICS, vol. 38, 2006, pages 441 - 446
J. ALLERGY CLIN. IMMUNOL., vol. 119, no. 2, 2007, pages 434 - 44
BRITISH JOURNAL OF DERMATOLOGY, vol. 161, 2009, pages 1387 - 1390
J. INVESTIGATIVE DERMATOLOGY, vol. 128, 2008, pages 2248 - 2258
FEBS LETTERS, vol. 554, 2003, pages 381 - 388
LANGERHANS, CELL, vol. 135, 2008, pages 561 - 571
NEUROPHARMACOLOGY, vol. 50, 2006, pages 512 - 520
NUTRITION & METABOLISM, vol. 5, 2008, pages 23
INFLAMMATION RESEARCH, vol. 60, no. 6, 2011, pages 589 - 596
J. INVESTIGATIVE DERMATOLOGY, vol. 128, 2008, pages 1430 - 1435
ARCH DERMATOL RES., vol. 295, 2004, pages 448 - 452
J. DERMATOLOGY, vol. 38, 2011, pages 685 - 692
J. INVEST. DERMATOL., vol. 129, no. 3, 2009, pages 682 - 689
FEBS LETT., vol. 554, no. 3, 2003, pages 381 - 388
GENE, vol. 108, 1991, pages 193 - 199
J. INVESTIGATIVE DERMATOLOGY, vol. 131, 2011, pages 1660 - 1667
See also references of EP 2878309A4

SHOJI, Takashi et al. (JP)
Takashi Shoji (JP)

View/Download PDF      PDF Help

Previous Patent: THREE-DIMENSIONAL OBJECT DETECTION DEVICE, THREE-DIMENSIONAL OBJECT DETECTION METHOD, AND FOREIGN SU...

Next Patent: WIND-POWERED THERMAL POWER GENERATION SYSTEM