FINELY PULVERIZED PHARMACEUTICAL COMPOSITION

Title:

FINELY PULVERIZED PHARMACEUTICAL COMPOSITION

Document Type and Number:

WIPO Patent Application WO/2010/087447

Kind Code:

A1

Abstract:

Disclosed are a composition containing a poorly soluble medicinal substance and having improved oral absorption, and a method for producing the composition. Specifically disclosed is a finely pulverized composition which contains a poorly soluble medicinal substance such as 22β-methoxyolean-12-ene-3β-,24(4β)-diol and a hydrophilic surfactant. Also specifically disclosed is a method for producing a finely pulverized composition, which is characterized in that a poorly soluble medicinal substance and a hydrophilic surfactant are first dispersed in a solvent, and then pulverized by a high-pressure homogenizer.

Inventors:

CHIKASE SHIGERU (JP)
KAWADA DAI (JP)

Application Number:

PCT/JP2010/051262

Publication Date:

August 05, 2010

Filing Date:

January 29, 2010

Export Citation:

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Assignee:

MEIJI SEIKA KAISHA (JP)
CHIKASE SHIGERU (JP)
KAWADA DAI (JP)

International Classes:

A61K47/20; A61K9/10; A61K9/14; A61K9/20; A61K31/075; A61K45/00; A61K47/26; A61K47/30; A61K47/32; A61K47/34; A61K47/38; A61P1/16

Domestic Patent References:

WO2006087919A1	2006-08-24
WO2008123093A1	2008-10-16

Foreign References:

JP2006520814A	2006-09-14
JP2006508105A	2006-03-09
JP2004501182A	2004-01-15
US5510118A	1996-04-23
JPH11106782A	1999-04-20
JPH10505628A	1998-06-02
JP3279574B2	2002-04-30
JP3602546B2	2004-12-15
JP2004099442A	2004-04-02

Other References:

See also references of EP 2392354A4
"Iyaku", 1983, JOURNAL CO. LTD., article "Saikin no seizai gijutu to sono oyo", pages: 157 - 159
"Iyaku", 1985, JOURNAL CO. LTD., article "Saikin no seizai gijutu to sono oyo", pages: 158 - 162