Title:
FLAVIVIRUS NS1 SUBUNIT VACCINE
Document Type and Number:
WIPO Patent Application WO2003048184
Kind Code:
A3
Abstract:
The present invention relates to NS1 proteins or parts thereof of Flaviviruses, in particular of Dengue viruses useful for vaccination against said Flavivirus and against one or more other Flaviviruses. The invention further concerns the NS1 protein or parts thereof of one Dengue virus serotype, in particular serotype 2, useful for vaccination against Dengue viruses from all serotypes. The invention further concerns DNA comprising an expression cassette coding for a Flavivirus NS1 or parts thereof, vectors, comprising said DNA and vaccines containing or expressing a Flavivirus NS1.
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Inventors:
HOWLEY PAUL (AU)
LEYRER SONJA (DE)
CARDOSA MARY JANE (MY)
HENRY SUM MAGDELINE SIA (MY)
LEYRER SONJA (DE)
CARDOSA MARY JANE (MY)
HENRY SUM MAGDELINE SIA (MY)
Application Number:
PCT/EP2002/012991
Publication Date:
January 29, 2004
Filing Date:
November 20, 2002
Export Citation:
Assignee:
BAVARIAN NORDIC AS (DK)
VENTURE TECHNOLOGIES SDN BHD (MY)
HOWLEY PAUL (AU)
LEYRER SONJA (DE)
CARDOSA MARY JANE (MY)
HENRY SUM MAGDELINE SIA (MY)
VENTURE TECHNOLOGIES SDN BHD (MY)
HOWLEY PAUL (AU)
LEYRER SONJA (DE)
CARDOSA MARY JANE (MY)
HENRY SUM MAGDELINE SIA (MY)
International Classes:
C12N15/09; A61K31/7088; A61K35/76; A61K39/12; A61K39/20; A61P31/12; A61P31/14; C07K14/18; C12N5/10; C12N15/40; C12N15/63; C12N15/863; A61K39/00; C07K; (IPC1-7): C07K14/18
Domestic Patent References:
| WO2001060847A2 | 2001-08-23 | |||
| WO1990001946A1 | 1990-03-08 | |||
| WO1998013500A2 | 1998-04-02 | |||
| WO2002042480A2 | 2002-05-30 |
Foreign References:
| US5824506A | 1998-10-20 |
Other References:
SCHLESINGER JJ ET AL: "Protection of mice against dengue 2 virus encephalitis by immunization with the dengue 2 virus non-structural glycoprotein NS1", JOURNAL OF GENERAL VIROLOGY, vol. 68, no. 3, 1987, pages 853 - 858, XP009015072, ISSN: 0022-1317
CHAMBERS TJ ET AL: "Vaccine development against dengue and Japanese encephalitis: report of a World Health Organization meeting", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 15, no. 14, 1 October 1997 (1997-10-01), pages 1494 - 1502, XP004090331, ISSN: 0264-410X
BRAY M ET AL: "Monkeys immunized with intertypic chimeric dengue viruses are protected against wild-type virus challenge.", JOURNAL OF VIROLOGY, vol. 70, no. 6, 1996, pages 4162 - 4166, XP002250234, ISSN: 0022-538X
FALCONAR AK ET AL: "Production of dimer-specific and dengue virus group cross-reactive mouse monoclonal antibodies to the dengue 2 virus non-structural glycoprotein NS1", JOURNAL OF GENERAL VIROLOGY, READING, BERKS, GB, vol. 72, no. 4, April 1991 (1991-04-01), pages 961 - 965, XP000890192, ISSN: 0022-1317
CHAMBERS TJ ET AL: "Vaccine development against dengue and Japanese encephalitis: report of a World Health Organization meeting", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 15, no. 14, 1 October 1997 (1997-10-01), pages 1494 - 1502, XP004090331, ISSN: 0264-410X
BRAY M ET AL: "Monkeys immunized with intertypic chimeric dengue viruses are protected against wild-type virus challenge.", JOURNAL OF VIROLOGY, vol. 70, no. 6, 1996, pages 4162 - 4166, XP002250234, ISSN: 0022-538X
FALCONAR AK ET AL: "Production of dimer-specific and dengue virus group cross-reactive mouse monoclonal antibodies to the dengue 2 virus non-structural glycoprotein NS1", JOURNAL OF GENERAL VIROLOGY, READING, BERKS, GB, vol. 72, no. 4, April 1991 (1991-04-01), pages 961 - 965, XP000890192, ISSN: 0022-1317
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