Title:
FLUORESCENT PROBE FOR LABELING M1 MACROPHAGES, AND M1 MACROPHAGE MONITORING SYSTEM USING SAME
Document Type and Number:
WIPO Patent Application WO/2023/191549
Kind Code:
A1
Abstract:
The present disclosure relates to: a novel compound comprising carbohydrate derivatives and fluorophores; a fluorescent probe for labeling M1 macrophages comprising same; and a visualization composition and kit comprising the fluorescent probe. A fluorescent probe for labeling M1 macrophages, according to one embodiment, shows excellent selectivity for M1 macrophages, and thus, the fluorescent probe can be applied to a M1 macrophage monitoring system, a method for providing information on M1 macrophages, and a method for providing information necessary for diagnosis of inflammatory diseases.
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Inventors:
CHANG YOUNG-TAE (KR)
KWON HAW-YOUNG (KR)
CHO HEEWON (KR)
KWON HAW-YOUNG (KR)
CHO HEEWON (KR)
Application Number:
PCT/KR2023/004294
Publication Date:
October 05, 2023
Filing Date:
March 30, 2023
Export Citation:
Assignee:
INST BASIC SCIENCE (KR)
POSTECH RES & BUSINESS DEV FOUND (KR)
POSTECH RES & BUSINESS DEV FOUND (KR)
International Classes:
G01N33/483; G01N33/50
Foreign References:
| KR20200110232A | 2020-09-23 |
Other References:
XU HU, LIU XINYU, YANG JINNA, LIU RAN, LI TAOLI, SHI YUNLI, ZHAO HONGXIA, GAO QINGZHI: "Cyanine-based 1-amino-1-deoxyglucose as fluorescent probes for glucose transporter mediated bioimaging", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM NL, vol. 474, no. 2, 1 May 2016 (2016-05-01), Amsterdam NL , pages 240 - 246, XP093094344, ISSN: 0006-291X, DOI: 10.1016/j.bbrc.2016.03.133
TAKASUGI TOMOHIRO; HANAOKA KENJIRO; SASAKI AYAKO; IKENO TAKAYUKI; KOMATSU TORU; UENO TASUKU; YAMADA KATSUYA; URANO YASUTERU: "Development of a platform for activatable fluorescent substrates of glucose transporters (GLUTs)", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 27, no. 10, 1 January 1900 (1900-01-01), AMSTERDAM, NL, pages 2122 - 2126, XP085664276, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2019.02.055
LICHA K, ET AL.: "Hydrophilic cyanine dyes as contrast agents for near‐infrared tumor imaging: Synthesis, photophysical properties and spectroscopic in vivo characterization SPECTROSCOPIC IN VIVO CHARACTERIZATION", PHOTOCHEMISTRY AND PHOTOBIOLOGY, WILEY-BLACKWELL PUBLISHING, INC., US, vol. 72, no. 03, 1 January 2000 (2000-01-01), US , pages 392 - 398, XP000992953, ISSN: 0031-8655, DOI: 10.1562/0031-8655(2000)072<0392:HCDACA>2.0.CO;2
DOSHI MONA, NIERENBERG DANIEL A., FLORES-FERNANDEZ ORIELYZ, DEME PRAGNEY, BECERRA EDILU, KHALED ANNETTE R., PARTHASARATHY SAMPATH: "Cypate and Cypate-Glucosamine as Near-Infrared Fluorescent Probes for In Vivo Tumor Imaging", MOLECULAR PHARMACOLOGY, AMERICAN SOCIETY FOR PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, US, vol. 95, no. 5, 1 May 2019 (2019-05-01), US , pages 475 - 489, XP093094349, ISSN: 0026-895X, DOI: 10.1124/mol.118.114199
CHO HEEWON, KWON HAW-YOUNG, SHARMA AMIT, LEE SUN HYEOK, LIU XIAO, MIYAMOTO NAOKI, KIM JONG-JIN, IM SIN-HYEOG, KANG NAM-YOUNG, CHAN: "Visualizing inflammation with an M1 macrophage selective probe via GLUT1 as the gating target", NATURE COMMUNICATIONS, vol. 13, no. 1, 10 October 2022 (2022-10-10), pages 5974, XP093094350, DOI: 10.1038/s41467-022-33526-z
TAKASUGI TOMOHIRO; HANAOKA KENJIRO; SASAKI AYAKO; IKENO TAKAYUKI; KOMATSU TORU; UENO TASUKU; YAMADA KATSUYA; URANO YASUTERU: "Development of a platform for activatable fluorescent substrates of glucose transporters (GLUTs)", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 27, no. 10, 1 January 1900 (1900-01-01), AMSTERDAM, NL, pages 2122 - 2126, XP085664276, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2019.02.055
LICHA K, ET AL.: "Hydrophilic cyanine dyes as contrast agents for near‐infrared tumor imaging: Synthesis, photophysical properties and spectroscopic in vivo characterization SPECTROSCOPIC IN VIVO CHARACTERIZATION", PHOTOCHEMISTRY AND PHOTOBIOLOGY, WILEY-BLACKWELL PUBLISHING, INC., US, vol. 72, no. 03, 1 January 2000 (2000-01-01), US , pages 392 - 398, XP000992953, ISSN: 0031-8655, DOI: 10.1562/0031-8655(2000)072<0392:HCDACA>2.0.CO;2
DOSHI MONA, NIERENBERG DANIEL A., FLORES-FERNANDEZ ORIELYZ, DEME PRAGNEY, BECERRA EDILU, KHALED ANNETTE R., PARTHASARATHY SAMPATH: "Cypate and Cypate-Glucosamine as Near-Infrared Fluorescent Probes for In Vivo Tumor Imaging", MOLECULAR PHARMACOLOGY, AMERICAN SOCIETY FOR PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, US, vol. 95, no. 5, 1 May 2019 (2019-05-01), US , pages 475 - 489, XP093094349, ISSN: 0026-895X, DOI: 10.1124/mol.118.114199
CHO HEEWON, KWON HAW-YOUNG, SHARMA AMIT, LEE SUN HYEOK, LIU XIAO, MIYAMOTO NAOKI, KIM JONG-JIN, IM SIN-HYEOG, KANG NAM-YOUNG, CHAN: "Visualizing inflammation with an M1 macrophage selective probe via GLUT1 as the gating target", NATURE COMMUNICATIONS, vol. 13, no. 1, 10 October 2022 (2022-10-10), pages 5974, XP093094350, DOI: 10.1038/s41467-022-33526-z
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PLUS INTERNATIONAL IP LAW FIRM (KR)
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