Title:
FLUOROUS TAGGING COMPOUNDS AND THEIR USE
Document Type and Number:
WIPO Patent Application WO2001085675
Kind Code:
A3
Abstract:
A method of increasing the fluorous nature of a compound includes the step of reacting the compound with at least one second compound having formula (I) wherein Rf is a fluorous group, Rs is a spacer group, d is 1 or 0, m is 1, 2 or 3, Ra is an alkyl group and X is a suitable leaving group. A compound has formula (II) wherein Rf is a fluorous group, n is an integer between 0 and 6, m is 1, 2 or 3, Ra is an alkyl group and X is a leaving group.
Inventors:
CURRAN DENNIS P
READ ROGER
LUO ZHIYONG
READ ROGER
LUO ZHIYONG
Application Number:
PCT/US2001/014350
Publication Date:
May 02, 2002
Filing Date:
May 03, 2001
Export Citation:
Assignee:
UNIV PITTSBURGH (US)
International Classes:
C07C69/96; C07C237/22; C07C237/42; C07C247/20; C07C255/61; C07C255/62; C07C269/04; C07C271/08; C07D207/14; C07D207/16; C07D211/62; C07D213/40; C07D217/06; C07D401/06; C07D405/06; (IPC1-7): C07C269/04; C07C255/33; C07C281/00; C07C69/96; C07B61/00; C07D401/06; C07D401/12; C07D211/60; C07D207/16
Foreign References:
| US3732274A | 1973-05-08 | |||
| GB1149280A | 1969-04-23 | |||
| US3627799A | 1971-12-14 |
Other References:
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; BASKAKOV Y.A ET AL: "Preparation of N-(hydroxyalkyl)- and N-[(aminocarbonyloxy)alkyl)]carbamates as stress-reducing plant growth regulators.", XP002186516, Database accession no. 1991:558738
HUDLICKY M: "NEW SYNTHESIS AND REACTIONS OF PERFLUORO-TERT-BUTYL CHLOROFORMATE", JOURNAL OF FLUORINE CHEMISTRY, ELSEVIER SEQUOIA, LAUSANNE, CH, vol. 20, 1982, pages 649 - 658, XP001011888, ISSN: 0022-1139
CURRAN, D.P.; LUO, Z.: "Fluorous Synthesis with FEwer Fluorines (Light Fluorous Synthesis): Separation of Tagged from Untagged Products by Solid-Phase Extraction with Fluorous Reverse-Phase Silica Gel", J. AM. CHEM. SOC., vol. 121, 1999, pages 9069 - 72, XP002186512
STUDER, A ET AL.: "Fluorous Synthesis: A fFluorous-Phase Strategy for Improving Separation Efficiency in Organic Synthesis", SCIENCE, vol. 275, 1997, pages 823 - 6, XP002186513
HUDLICKY M: "NEW SYNTHESIS AND REACTIONS OF PERFLUORO-TERT-BUTYL CHLOROFORMATE", JOURNAL OF FLUORINE CHEMISTRY, ELSEVIER SEQUOIA, LAUSANNE, CH, vol. 20, 1982, pages 649 - 658, XP001011888, ISSN: 0022-1139
CURRAN, D.P.; LUO, Z.: "Fluorous Synthesis with FEwer Fluorines (Light Fluorous Synthesis): Separation of Tagged from Untagged Products by Solid-Phase Extraction with Fluorous Reverse-Phase Silica Gel", J. AM. CHEM. SOC., vol. 121, 1999, pages 9069 - 72, XP002186512
STUDER, A ET AL.: "Fluorous Synthesis: A fFluorous-Phase Strategy for Improving Separation Efficiency in Organic Synthesis", SCIENCE, vol. 275, 1997, pages 823 - 6, XP002186513
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