Title:
FORMULATION COMPRISING LIPOSOMES
Document Type and Number:
WIPO Patent Application WO/2020/129826
Kind Code:
A1
Abstract:
A formulation comprising liposomes, wherein the liposomes comprise, based on the liposome, 0.7 to 3.0 mol% of eritoran or a pharmaceutically acceptable salt thereof and 0.5 to 3.0 mol% of a PEGylated phospholipid.
Inventors:
ISHIHARA HIROSHI (JP)
HATA KATSURA (JP)
MUTO HIROKI (JP)
HIRD GEOFF (US)
HATA KATSURA (JP)
MUTO HIROKI (JP)
HIRD GEOFF (US)
Application Number:
PCT/JP2019/048842
Publication Date:
June 25, 2020
Filing Date:
December 13, 2019
Export Citation:
Assignee:
EISAI R&D MAN CO LTD (JP)
International Classes:
A61K31/7028; A61K9/127; A61K47/24
Domestic Patent References:
| WO2012047656A1 | 2012-04-12 | |||
| WO2018181963A1 | 2018-10-04 |
Foreign References:
| US5681824A | 1997-10-28 | |||
| US20060222655A1 | 2006-10-05 |
Other References:
Z. PANAGI , K AVGOUSTAKIS , G EVANGELATOS , D S ITHAKISSIOS : "Protein-induced CF release from liposomes in vitro and its correlation with the BLOOD/RES biodistribution of liposomes", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 163, 1 January 1998 (1998-01-01), pages 103 - 114, XP055714617, DOI: 10.1016/S0378-5173(97)00370-0
Y. PARK, HUANG L.: "Distribution Within the Organs of a Reticuloendothelial System of Liposomes Containing Lipid A", JOURNAL OF DRUG TARGETING, vol. 1, no. 4, 20 January 1993 (1993-01-20), GB, pages 325 - 330, XP055714619, ISSN: 1061-186X, DOI: 10.3109/10611869308996091
D H HORBER , C OTTIGER , H SCOTT , R A SCHWENDENER : "Pharmacokinetic Properties and Interactions with Blood Components of N4-Hexadecyl-1-b-D-arabinofuranosylcytosine (NHAC) Incorporated into Liposomes", JOURNAL OF PHARMACY AND PHARMACOLOGY, vol. 47, no. 4, 1 April 1995 (1995-04-01), pages 282 - 288, XP009527769, ISSN: 2042-7158, DOI: 10.1111/j.2042-7158.1995.tb05796.x
See also references of EP 3897665A4
Y. PARK, HUANG L.: "Distribution Within the Organs of a Reticuloendothelial System of Liposomes Containing Lipid A", JOURNAL OF DRUG TARGETING, vol. 1, no. 4, 20 January 1993 (1993-01-20), GB, pages 325 - 330, XP055714619, ISSN: 1061-186X, DOI: 10.3109/10611869308996091
D H HORBER , C OTTIGER , H SCOTT , R A SCHWENDENER : "Pharmacokinetic Properties and Interactions with Blood Components of N4-Hexadecyl-1-b-D-arabinofuranosylcytosine (NHAC) Incorporated into Liposomes", JOURNAL OF PHARMACY AND PHARMACOLOGY, vol. 47, no. 4, 1 April 1995 (1995-04-01), pages 282 - 288, XP009527769, ISSN: 2042-7158, DOI: 10.1111/j.2042-7158.1995.tb05796.x
See also references of EP 3897665A4
Attorney, Agent or Firm:
INABA, Yoshiyuki et al. (JP)
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