FORMULATION CONTAINING HMGB1 PARTIAL PEPTIDE

Title:

FORMULATION CONTAINING HMGB1 PARTIAL PEPTIDE

Document Type and Number:

WIPO Patent Application WO/2021/215375

Kind Code:

A1

Abstract:

This pharmaceutical composition, which contains a substance described in any of the following (a) to (c), an organic acid, an organic acid metal salt, and a sugar and/or a sugar alcohol and which has a pH of 3.0-4.5 when dissolved in distilled water for injection, can stabilize the substance described in any of the following (a) to (c): (a) an HMGB1 fragment peptide that contains the amino acid sequence of SEQ ID NO: 1, or an acid addition salt of said peptide; (b) a peptide that contains the amino acid sequence of SEQ ID NO: 1, in which one or more amino acids have been replaced, deleted, inserted, or added, and that has activity to stimulate cell migration, or an acid addition salt of said peptide; and (c) a peptide that contains an amino acid sequence having a sequence identity of approximately 80% or more to the amino acid sequence of SEQ ID NO: 1 and that has activity to stimulate cell migration, or an acid addition salt of said peptide.

Inventors:

MATSUOKA NAO (JP)
HATANO SHUICHI (JP)
KUGA YUYA (JP)
OKABE MAKI (JP)
YAMAZAKI TAKEHIKO (JP)
YOKOTA KOICHI (JP)

Application Number:

PCT/JP2021/015792

Publication Date:

October 28, 2021

Filing Date:

April 19, 2021

Export Citation:

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Assignee:

SHIONOGI & CO (JP)
STEMRIM INC (JP)

International Classes:

A61K38/16; A61K9/08; A61K9/19; A61K47/02; A61K47/04; A61K47/12; A61K47/26; A61P43/00; C12N15/12

Domestic Patent References:

WO2014065347A1	2014-05-01
WO2019156137A1	2019-08-15
WO2012147470A1	2012-11-01
WO2014065347A1	2014-05-01
WO2008102849A1	2008-08-28
WO2013154045A1	2013-10-17

Foreign References:

JP2019189633A	2019-10-31
JP2000169372A	2000-06-20

Other References: