Title:
FOXP2 AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2004022104
Kind Code:
A3
Abstract:
The present invention relates to FOXP2 and in particular to the use of FOXP2 in treating or identifying patients with cancer. More particularly the invention discloses a method of treating a disorder in a patient characterised by reduced expression of FOXP2 protein, which method comprises, administering to a patient in need thereof a therapeutic amount of any of a nucleic acid molecule encoding said FOXP2 protein, FOXP2 protein or a composition capable of stimulating an increase in FOXP2 protein expression in the tissues of said patient. Also covered by the application are further methods, compositions, vectors, kits and assays relating to FOXP2.
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Inventors:
BANHAM ALISON HILARY (GB)
BROWN PHILIP JAMES (GB)
FISHER SIMON EDWARD (GB)
BROWN PHILIP JAMES (GB)
FISHER SIMON EDWARD (GB)
Application Number:
PCT/GB2003/003884
Publication Date:
July 29, 2004
Filing Date:
September 08, 2003
Export Citation:
Assignee:
ISIS INNOVATION (GB)
BANHAM ALISON HILARY (GB)
BROWN PHILIP JAMES (GB)
FISHER SIMON EDWARD (GB)
BANHAM ALISON HILARY (GB)
BROWN PHILIP JAMES (GB)
FISHER SIMON EDWARD (GB)
International Classes:
C07K14/47; A61K38/00; A61K48/00; (IPC1-7): A61K48/00; C07K14/47; C07K14/72
Other References:
LAI CECILIA S L ET AL: "A forkhead-domain gene is mutated in a severe speech and language disorder", NATURE (LONDON), vol. 413, no. 6855, 4 October 2001 (2001-10-04), pages 519 - 523, XP002270201, ISSN: 0028-0836
PINKER S: "Talk of genetics and vice versa.", NATURE. ENGLAND 4 OCT 2001, vol. 413, no. 6855, 4 October 2001 (2001-10-04), pages 465 - 466, XP002270200, ISSN: 0028-0836
SHU WEIGUO ET AL: "Characterization of a new subfamily of winged-helix/forkhead (Fox) genes that are expressed in the lung and act as transcriptional repressors", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 276, no. 29, 20 July 2001 (2001-07-20), pages 27488 - 27497, XP002264690, ISSN: 0021-9258
PINKER S: "Talk of genetics and vice versa.", NATURE. ENGLAND 4 OCT 2001, vol. 413, no. 6855, 4 October 2001 (2001-10-04), pages 465 - 466, XP002270200, ISSN: 0028-0836
SHU WEIGUO ET AL: "Characterization of a new subfamily of winged-helix/forkhead (Fox) genes that are expressed in the lung and act as transcriptional repressors", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 276, no. 29, 20 July 2001 (2001-07-20), pages 27488 - 27497, XP002264690, ISSN: 0021-9258
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