FUCOIDAN-DERIVED OLIGOSACCHARIDE

Title:

FUCOIDAN-DERIVED OLIGOSACCHARIDE

Document Type and Number:

WIPO Patent Application WO/2007/013609

Kind Code:

A1

Abstract:

Fucoidan is a sulfated polysaccharide having an extremely large molecular weight. In the development of pharmaceuticals and health foods using fucoidan, there are problems with respect to absorption property, antigenicity, homogeneity, anti-coagulant activity and the like. Then, provided is a low molecular weight compound derived from a low molecular weight fucoidan having a specified structure and function, which can overcome the above-mentioned problems. Novel fucoidan oligosaccharides (I) to (XI) as disclosed in the description can be found by the hydrolysis of fucoidan with an acid. It is found that these oligosaccharides have various immune function-modulating effects including IFN-γ-inducing capability, IL-10 and 12-inducing capability, dendritic cell-maturating effect and CTL activity-inducing effect.

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Inventors:

NONAKA YUJI (JP)
YASUMOTO TAKESHI (JP)
NAOKI HIDEO (JP)
KUSUMOTO TOSHIHIDE (JP)

Application Number:

PCT/JP2006/315020

Publication Date:

February 01, 2007

Filing Date:

July 28, 2006

Export Citation:

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Assignee:

SUNTORY LTD (JP)
TROPICAL TECHNOLOGY CT LTD (JP)
NONAKA YUJI (JP)
YASUMOTO TAKESHI (JP)
NAOKI HIDEO (JP)
KUSUMOTO TOSHIHIDE (JP)

International Classes:

C07H7/033; A23L1/30; A61K8/73; A61K31/7016; A61K31/702; A61K31/7024; A61P37/02; A61Q19/00; C07H11/00; C07H13/06

Domestic Patent References:

WO2001013925A1

2001-03-01

Foreign References:

JP2005110675A	2005-04-28
JP2000351790A	2000-12-19
JP2005082806A	2005-03-31
JPH11228602A	1999-08-24

Other References:

KUSUMOTO T. ET AL.: "Okinawa Mozuku Yurai Fucoidan ni Kansuru Seibun Kenkyu", NIPPON YAKUGAKUKEI NENKAI KOEN YOSHISHU, vol. 124, no. 2, 2004, pages 122, XP003008261
NAGAOKA M. ET AL.: "Structural study of fucoidan from Cladosiphon okamuranus TOKIDA", GLYCOCONJUGATE JOURNAL, vol. 16, no. 1, 1999, pages 19 - 26, XP002943440

Attorney, Agent or Firm:

SHAMOTO, Ichio et al. (Section 206 New Ohtemachi Bldg., 2-1, Ohtemachi 2-chom, Chiyoda-ku Tokyo 04, JP)

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