Title:
FUNCTIONAL SILK FIBROIN DRUG CARRIER AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2023/056717
Kind Code:
A1
Abstract:
Provided is a preparation method for a functional silk fibroin (SF) drug carrier, comprising: degumming, dissolving, dialyzing, filtering, and concentrating Bombyx mori silkworm silk to obtain an SF dissolving solution; using a cross-linking agent to activate ketone thioketal (TK) having carboxyl groups at two ends, and mixing TK with the SF dissolving solution for reaction to obtain a reacted solution; and adding the reacted solution into a mixed system of ethanol absolute and polyvinyl alcohol, stirring, freezing, unfreezing, centrifuging, and finally freeze-drying the precipitate to obtain the SF drug carrier. Provided is using most functional groups contained in SF molecules, i.e., hydroxyl groups to prepare ROS-responsive drug-loaded SF/TK nanoparticles. On the basis of chemical structural characteristics of the SF molecules, various drugs having different surface properties can be loaded, a series of SF drug carriers having an intelligent responsive delivery function are developed, and the accuracy and effectiveness of drug treatment at diseased tissue sites are improved.
Inventors:
WANG JIANNAN (CN)
LUO YUANZE (CN)
ZHENG CHANGDONG (CN)
YI HONGGEN (CN)
LUO YUANZE (CN)
ZHENG CHANGDONG (CN)
YI HONGGEN (CN)
Application Number:
PCT/CN2021/142944
Publication Date:
April 13, 2023
Filing Date:
December 30, 2021
Export Citation:
Assignee:
UNIV SOOCHOW (CN)
International Classes:
A61K47/64; A61K41/00; A61K47/69; A61P29/00; A61P35/00; B82Y5/00
Foreign References:
| CN113730599A | 2021-12-03 | |||
| CN106046135A | 2016-10-26 | |||
| EP2210971A1 | 2010-07-28 | |||
| KR20160036523A | 2016-04-04 | |||
| CN101244277A | 2008-08-20 | |||
| CN110354273A | 2019-10-22 |
Other References:
"Master's Thesis", 1 June 2020, SUZHOU UNIVERSITY, CN, article ZHANG, LING: "Study on Preparation and Structural Properties of ROS-Responsive Silk Fibroin Composites", pages: 1 - 73, XP009545060, DOI: 10.27351/d.cnki.gszhu.2020.001068
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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