Title:
FUSED AZOLE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2013/147117
Kind Code:
A1
Abstract:
Provided is a therapeutic or prophylactic agent for mood disorders, anxiety, schizophrenia, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorders, hypertension, digestive diseases, drug dependence, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, head injury, inflammation, immune related diseases, depilation, and so on. More specifically, provided is a fused azole derivative represented by general formula (I), which has arginine vasopressin 1b receptor antagonism, or a pharmaceutically acceptable salt thereof.
Inventors:
YOSHINAGA MITSUKANE (JP)
ISHIZAKA TOMOKO (JP)
WAKASUGI DAISUKE (JP)
SHIROKAWA SHIN-ICHI (JP)
HATTORI NOBUTAKA (JP)
KASHIWA SHUHEI (JP)
KUWADA TAKESHI (JP)
SHIMAZAKI YOUICHI (JP)
ISHIZAKA TOMOKO (JP)
WAKASUGI DAISUKE (JP)
SHIROKAWA SHIN-ICHI (JP)
HATTORI NOBUTAKA (JP)
KASHIWA SHUHEI (JP)
KUWADA TAKESHI (JP)
SHIMAZAKI YOUICHI (JP)
Application Number:
PCT/JP2013/059457
Publication Date:
October 03, 2013
Filing Date:
March 29, 2013
Export Citation:
Assignee:
TAISHO PHARMACEUTICAL CO LTD (JP)
International Classes:
C07D209/10; A61K31/405; A61K31/4184; A61K31/438; A61K31/454; A61K31/4545; A61K31/5377; A61K31/5386; A61K31/55; A61P1/14; A61P7/10; A61P9/10; A61P9/12; A61P17/14; A61P25/00; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/28; A61P29/00; A61P37/00; A61P43/00; C07D231/56; C07D235/18; C07D401/04; C07D401/12; C07D403/12; C07D471/04; C07D491/08; C07D491/107
Domestic Patent References:
| WO2009017236A1 | 2009-02-05 | |||
| WO2011096461A1 | 2011-08-11 | |||
| WO2009130232A1 | 2009-10-29 | |||
| WO2009130231A1 | 2009-10-29 | |||
| WO2001055130A2 | 2001-08-02 | |||
| WO2005021534A1 | 2005-03-10 | |||
| WO2005030755A1 | 2005-04-07 | |||
| WO2006095014A1 | 2006-09-14 | |||
| WO2006102308A2 | 2006-09-28 | |||
| WO2006133242A2 | 2006-12-14 | |||
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| WO2008025736A1 | 2008-03-06 | |||
| WO2008033757A2 | 2008-03-20 | |||
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| WO2009017236A1 | 2009-02-05 | |||
| WO2009130231A1 | 2009-10-29 | |||
| WO2009130232A1 | 2009-10-29 | |||
| WO2011096461A1 | 2011-08-11 | |||
| WO2006021886A1 | 2006-03-02 |
Foreign References:
| JP2010502745A | 2010-01-28 | |||
| JP2010502746A | 2010-01-28 | |||
| JP2008532981A | 2008-08-21 |
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See also references of EP 2832722A4
LOLAIT S; BROWNSTEIN M, PNAS, vol. 92, 1995, pages 6783 - 6787
VACCARI C; OSTROWSKI N, ENDOCRINOLOGY, vol. 139, 1998, pages 5015 - 5033
HERNANDO F; BURBACH J, ENDOCRINOLOGY, vol. 142, 2001, pages 1659 - 1668
WERSINGER SR; YOUNG WS, MOL. PSYCHIATRY, vol. 7, 2002, pages 975 - 984
LIEBSCH G; ENGELMANN M, NEUROSCI. LETT., vol. 217, 1996, pages 101 - 104
GAL CS; LE FUR G, JPET, vol. 300, 2002, pages 1122 - 1130
GRIEBEL G; SOUBRIE P, PNAS, vol. 99, 2002, pages 6370 - 6375
JACK D. SCOTT ET AL., BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19, no. 21, 2009, pages 6018 - 6022
CHRIS A S, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 21, 2011, pages 92 - 96
JAMES B, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 21, 2011, pages 3603 - 3607
ZHOU Y ET AL., NEUROPSYCHOPHARMACOLOGY, vol. 36, 2011, pages 2062 - 2075
ZHOU Y ET AL., ALCOHOL CLIN EXP RES, vol. 35, 2011, pages 1876 - 1883
THE COMPREHENSIVE OVERVIEW OF THE MITSUNOBU REACTION IS FOUND IN SYNTHESIS, 1981, pages 1 - 28
CHEM. ASIAN J., vol. 2, 2007, pages 1340 - 1355
CHEM. PHARM. BULL., vol. 51, no. 4, 2003, pages 474 - 476
M. PAULUCKI; J. P. WOLFE; S. L. BUCHWALD, J. AM. CHEM. SOC., vol. 118, 1996, pages 10333
G. MANN; J. F. HARTWIG, J. AM. CHEM. SOC., vol. 118, 1996, pages 13109
M. WATANABE; M. NISHIYAMA; Y. KOIE, TETRAHEDRON LETT., vol. 40, 1999, pages 8837
Q. SHELBY; N. KATAOKA; G. MANN; J. F. HARTWIG, J. AM. CHEM. SOC., vol. 122, 2000, pages 10718
K. E. TORRACA; S. KUWABE; S. L. BUCHWALD, J. AM. CHEM. SOC., vol. 122, 2000, pages 12907
C. A. PARRISH; S. L. BUCHWALD, J. ORG. CHEM., vol. 66, 2001, pages 2498
P. M. KAREN; E. TORRACA; X. HUANG; C. A. PARRISH; S. L. BUCHWALD, J. AM. CHEM. SOC, 2001, pages 10770 - 10771
ANDREI V/VOROGUSHIN; XIAOHUA HUANG; STEPHEN L. BUCHWALD, J. AM. CHEM. SOC., 2005, pages 8146 - 8149
"Protective Groups in Organic Synthesis", JOHN WILEY & SONS, INC
TETRAHEDRON LETT., vol. 50, 1975, pages 4467
COMPREHENSIVE ORGANIC SYNTHESIS, vol. 3, 1991, pages 521
ANGEW. CHEM. INT., ED., vol. 40, 2001, pages 4544
CHEM. REV., vol. 95, 1995, pages 2457 - 2483
"Comprehensive Organic Transformations", 1999, JOHN WILEY & SONS, INC
LEY, S. V.; THOMAS, A. W, ANGEW. CHEM., INT. ED., vol. 42, 2003, pages 5400 - 5449
ANGEW. CHEM. INT., ED., vol. 43, 2004, pages 4704 - 4734
J. F. W. MCOMIE, PROTECTIVE GROUPS IN ORGANIC CHEMISTRY
T. W. GREENE; P. G. M. WUTS, PROTECTIVE GROUPS IN ORGANIC SYNTHESIS
ANGEWANDTE CHEMIE, vol. 47, no. 34, 2008, pages 6338 - 6361
See also references of EP 2832722A4
Attorney, Agent or Firm:
ONO, Shinjiro et al. (JP)
Ono Shinjiro (JP)
Ono Shinjiro (JP)
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