Title:
FUSED BICYCLIC COMPOUND FOR INHIBITING ACTIVITY OF TYROSINE KINASE
Document Type and Number:
WIPO Patent Application WO/2018/033091
Kind Code:
A1
Abstract:
A fused bicyclic compound having an effect in inhibition of the activity of a tyrosine kinase, and preparation and use thereof are disclosed. In particular, a compound of formula (I) or a pharmaceutically acceptable salt, a stereoisomer, a solvate, a hydrate, a polymorph, a prodrug or an isotopic variation thereof, as well as a pharmaceutical composition comprising same are disclosed. As a selective irreversible inhibitor of Bruton's tyrosine kinase, the described compound can be used for preventing or treating diseases such as inflammation, autoimmune diseases (such as rheumatoid arthritis), xenogeneic immune diseases and cancers.
Inventors:
WANG YIHAN (CN)
XING QINGFENG (CN)
XING QINGFENG (CN)
Application Number:
PCT/CN2017/097633
Publication Date:
February 22, 2018
Filing Date:
August 16, 2017
Export Citation:
Assignee:
SHENZHEN TARGETRX INC (CN)
International Classes:
C07D487/04; A61P29/00; A61P35/00; A61P35/02; A61P37/02
Domestic Patent References:
| WO2016024227A1 | 2016-02-18 |
Foreign References:
| CN103319488A | 2013-09-25 | |||
| CN101610676A | 2009-12-23 | |||
| CN102887900A | 2013-01-23 | |||
| CN102918040A | 2013-02-06 | |||
| CN103857396A | 2014-06-11 | |||
| CN103889987A | 2014-06-25 | |||
| CN104080789A | 2014-10-01 |
Other References:
DATABASE CAS 8 March 2016 (2016-03-08), ANONYMOUS, XP055576367, retrieved from REGISTRY Database accession no. 1882056-72-5
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