FUSED BICYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE

Title:

FUSED BICYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE

Document Type and Number:

WIPO Patent Application WO/2024/046420

Kind Code:

A1

Abstract:

The present disclosure relates to a fused bicyclic compound, and a preparation method therefor and the use thereof in medicine. Specifically, the present disclosure relates to a fused bicyclic compound as shown in general formula (I), a preparation method therefor, a pharmaceutical composition comprising the compound, and the use thereof as a therapeutic agent, in particular, the use thereof as a PARP1 inhibitor and the use thereof for treating and/or preventing cancers.

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Inventors:

LI XIN (CN)
DONG HUAIDE (CN)
HE FENG (CN)

Application Number:

PCT/CN2023/116099

Publication Date:

March 07, 2024

Filing Date:

August 31, 2023

Export Citation:

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Assignee:

JIANGSU HENGRUI PHARMACEUTICALS CO LTD (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)

International Classes:

C07D519/00; A61K31/444; A61P7/00; A61P7/02; A61P35/00; A61P35/02; C07D471/04; C07D487/04

Domestic Patent References:

WO2022228387A1	2022-11-03
WO2023051812A1	2023-04-06
WO2007138355A1	2007-12-06

Foreign References:

CN115403595A	2022-11-29
CN115232154A	2022-10-25
CN114144413A	2022-03-04
CN104918917A	2015-09-16
EP1396488A1	2004-03-10

Attorney, Agent or Firm:

GE CHENG & CO., LTD. (CN)

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