FUSION PROTEIN HAVING C-TERMINAL SEQUENCE OF LAMPREY-DERIVED VLRB PROTEIN CONNECTED TO HAGFISH-DERIVED VLRB PROTEIN HAVING HYDROPHOBIC TAIL DOMAIN REMOVED THEREFROM, AND USE THEREOF

Title:

FUSION PROTEIN HAVING C-TERMINAL SEQUENCE OF LAMPREY-DERIVED VLRB PROTEIN CONNECTED TO HAGFISH-DERIVED VLRB PROTEIN HAVING HYDROPHOBIC TAIL DOMAIN REMOVED THEREFROM, AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2018/212467

Kind Code:

A1

Abstract:

The present invention relates to a multivalent antibody having an increased binding force with respect to a target antigen. The multivalent antibody has a fusion protein self-assembled into a multimer, the fusion protein having a C-terminus of a lamprey-derived variable lymphocyte receptor B (VLRB) protein connected to a hagfish-derived VLRB protein having a hydrophobic tail domain removed therefrom.

Inventors:

JUNG TAE SUNG (KR)
KIM GYUNG DONG (KR)
LEE JUNG SUK (KR)
KIM JAESUNG (KR)
KIM YOUNG RIM (KR)
IM SE PYUNG (KR)

Application Number:

PCT/KR2018/004464

Publication Date:

November 22, 2018

Filing Date:

April 18, 2018

Export Citation:

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Assignee:

NAT UNIV GYEONGSANG IACF (KR)
IMMUCELL CO LTD (KR)

International Classes:

C07K14/46; C07K14/725; G01N33/53

Domestic Patent References:

WO2013078425A1	2013-05-30
WO2016097369A1	2016-06-23
WO2008016854A2	2008-02-07

Foreign References:

KR20160015891A	2016-02-15
KR20160147787A	2016-12-23

Attorney, Agent or Firm:

CHOI, Kyu Whan (KR)

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