Title:
FUSION PROTEIN HAVING MOUSE ANTIBODY-DERIVED Fc DOMAIN CONNECTED TO HAGFISH-DERIVED VLRB PROTEIN HAVING HYDROPHOBIC TAIL DOMAIN REMOVED THEREFROM, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/212468
Kind Code:
A1
Abstract:
The present invention relates to a multivalent antibody having an increased binding force with respect to a target antigen. The multivalent antibody has a fusion protein formed into a dimeric or tetrameric multimer, the fusion protein having a hagfish-derived variable lymphocyte receptor B (VLRB) having a hydrophobic tail domain removed therefrom, an immunoglobulin Fc domain, a linker and an immunoglobulin J chain sequentially connected.
Inventors:
JUNG TAE SUNG (KR)
KIM GYUNG DONG (KR)
LEE JUNG SUK (KR)
IM SE PYUNG (KR)
KIM YOUNG RIM (KR)
KIM JAESUNG (KR)
KIM GYUNG DONG (KR)
LEE JUNG SUK (KR)
IM SE PYUNG (KR)
KIM YOUNG RIM (KR)
KIM JAESUNG (KR)
Application Number:
PCT/KR2018/004465
Publication Date:
November 22, 2018
Filing Date:
April 18, 2018
Export Citation:
Assignee:
NAT UNIV GYEONGSANG IACF (KR)
IMMUCELL CO LTD (KR)
IMMUCELL CO LTD (KR)
International Classes:
C07K14/46; C07K14/725; G01N33/53
Domestic Patent References:
| WO2013078425A1 | 2013-05-30 | |||
| WO2008016854A2 | 2008-02-07 |
Foreign References:
| US20110230374A1 | 2011-09-22 |
Other References:
TASUMI, S. ET AL.: "High-affinity Lamprey VLRA and VLRB Monoclonal Antibodies", PNAS, vol. 106, no. 31, 4 August 2009 (2009-08-04), pages 12891 - 12896, XP055049062
HERRIN, B. R. ET AL.: "Structure and Specificity of Lamprey Monoclonal Antibodies", PNAS, vol. 105, no. 6, 31 January 2008 (2008-01-31), pages 2040 - 2045, XP002671201
HERRIN, B. R. ET AL.: "Structure and Specificity of Lamprey Monoclonal Antibodies", PNAS, vol. 105, no. 6, 31 January 2008 (2008-01-31), pages 2040 - 2045, XP002671201
Attorney, Agent or Firm:
CHOI, Kyu Whan (KR)
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