Title:
GABAB RECEPTOR NEGATIVE ALLOSTERIC MODULATOR AND MEDICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/051760
Kind Code:
A1
Abstract:
The present invention relates to the field of pharmaceutical chemistry. In particular, the present invention relates to a γ-aminobutyric acid type-B receptor (Gamma Aminobutyric Acid B Receptor, referred to as a GABABR or GABAB receptor for short) ligand molecule and a medicinal use thereof, wherein the ligand molecule has the structure of formula I. The ligand molecule which the present invention relates to is a GABAB receptor negative allosteric modulator, can non-competitively inhibit GABAB receptor agonist-induced activation of the receptor, and can be used to prepare drugs for the treatment of GABAB receptor hyperexcitability-related diseases, wherein the diseases comprise epilepsy, anxiety, depression or low cognitive ability caused by nerve damage, and so on.
More Like This:
Inventors:
NAN FAJUN (CN)
LIU JIANFENG (CN)
CHEN LINHAI (CN)
SUN BING (CN)
LIU JIANFENG (CN)
CHEN LINHAI (CN)
SUN BING (CN)
Application Number:
PCT/CN2014/088328
Publication Date:
April 16, 2015
Filing Date:
October 10, 2014
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA (CN)
UNIV HUAZHONG SCIENCE TECH (CN)
UNIV HUAZHONG SCIENCE TECH (CN)
International Classes:
C07C39/00; A61K31/00; C07C49/04; C07C49/20
Foreign References:
| US3714122A | 1973-01-30 | |||
| CN103025808A | 2013-04-03 |
Attorney, Agent or Firm:
XU&PARTNERS,LLC. (CN)
上海一平知识产权代理有限公司 (CN)
上海一平知识产权代理有限公司 (CN)
Download PDF: