Title:
GAMMA-INTERFERON ACTIVITY MODULATING AGENT
Document Type and Number:
WIPO Patent Application WO1997003700
Kind Code:
A3
More Like This:
Inventors:
LORTAT-JACOB HUGUES (FR)
Application Number:
PCT/FR1996/001141
Publication Date:
March 20, 1997
Filing Date:
July 19, 1996
Export Citation:
Assignee:
PASTEUR INSTITUT (FR)
PARTEUROP DEV (FR)
LORTAT JACOB HUGUES (FR)
PARTEUROP DEV (FR)
LORTAT JACOB HUGUES (FR)
International Classes:
A61K38/21; A61K47/48; (IPC1-7): A61K47/48
Other References:
LORTAT-JACOB H ET AL: "Interferon-gamma binds to heparan sulfate by a cluster of amino acids located in the C-terminal part of the molecule.", FEBS LETT, LE11 MARS 1991, VOL. 280, NO. 1, PAGE(S) 152-4, XP002001351
DAUEBENER W ET AL: "Heparin inhibits the antiparasitic and immune modulatory effects of human recombinant interferon-gamma", EUROPEAN JOURNAL OF IMMUNOLOGY, VOL. 25, NO. 3, PAGE(S) 688-692, March 1995 (1995-03-01), XP000568802
LORTAT-JACOB H ET AL: "Matrice conjonctive et localisation d'un signal biologique: mise en evidence d'un recepteur matriciel pour l'interferon- gamma dans les membranes basale", C R ACAD SCI III, 1990, VOL. 311, NO. 4, PAGE(S) 143-7, FRANCE, XP002001352
LORTAT-JACOB H ET AL: "Binding of interferon-gamma to heparan sulfate is restricted to the heparin-like domains and involves carboxylic--but not N-sulfated--groups.", BIOCHIM BIOPHYS ACTA, 15-9-1992, VOL. 1117, NO. 2, PAGE(S) 126-30, NL, XP000568807
LORTAT-JACOB H ET AL: "High-affinity binding of interferon-gamma to a basement membrane complex (matrigel).", J CLIN INVEST, MARS 1991, VOL. 87, NO. 3, PAGE(S) 878-83, US, XP000568805
LORTAT-JACOB H ET AL: "Molecular organization of the interferon gamma-binding domain in heparan sulphate.", BIOCHEM J, SEP 1 1995, VOL. 310, NO. PT 2, PAGE(S) 497-505, ENGLAND, XP000568803
LORTAT-JACOB, H. ET AL: "Interferon - gamma, an anti-fibrogenic cytokine which binds to heparan sulfate", PATHOL., RES. PRACT., VOL. 190, NO. 9-10, PAGE(S) 920-2, 1994, XP000616388
LORTAT-JACOB, H. ET AL: "Interferon - gamma C-terminal function: new working hypothesis. Heparan sulfate and heparin, new targets for IFN-gamma, protect, relax the cytokine and regulate its activity", CELL. MOL. BIOL., VOL. 37, NO. 3, PAGE(S) 253-60, 1991, XP000616389
LIAN, REBECCA H. ET AL: "IFN-.gamma.-induced MHC class II gene expression is suppressed in endothelial cells by dextran sulfate", J. IMMUNOL., VOL. 157, NO. 2, PAGE(S) 864-873, 15 July 1996 (1996-07-15), XP002023901
LORTAT-JACOB, HUGUES ET AL: "Heparin decreases the blood clearance of interferon -. gamma. and increases its activity by limiting the processing of its carboxyl-terminal sequence", J. BIOL. CHEM., VOL. 271, NO. 27, PAGE(S) 16139-16143, 5 July 1996 (1996-07-05), XP002023902
RIX, D. A. ET AL: "Role of glycosaminoglycans (GAGs) in regulation of the immunogenicity of human vascular endothelial cells", CLIN. EXP. IMMUNOL., VOL. 104, NO. 1, PAGE(S) 60-5, April 1996 (1996-04-01), XP000616393
LORTAT-JACOB, HUGUES ET AL: "Non-receptor-mediated tissue localization of human interferon -. gamma.: role of heparan sulfate /heparin-like molecules", CYTOKINE, VOL. 8, NO. 7, PAGE(S) 557-566, July 1996 (1996-07-01), XP000616381
DAUEBENER W ET AL: "Heparin inhibits the antiparasitic and immune modulatory effects of human recombinant interferon-gamma", EUROPEAN JOURNAL OF IMMUNOLOGY, VOL. 25, NO. 3, PAGE(S) 688-692, March 1995 (1995-03-01), XP000568802
LORTAT-JACOB H ET AL: "Matrice conjonctive et localisation d'un signal biologique: mise en evidence d'un recepteur matriciel pour l'interferon- gamma dans les membranes basale", C R ACAD SCI III, 1990, VOL. 311, NO. 4, PAGE(S) 143-7, FRANCE, XP002001352
LORTAT-JACOB H ET AL: "Binding of interferon-gamma to heparan sulfate is restricted to the heparin-like domains and involves carboxylic--but not N-sulfated--groups.", BIOCHIM BIOPHYS ACTA, 15-9-1992, VOL. 1117, NO. 2, PAGE(S) 126-30, NL, XP000568807
LORTAT-JACOB H ET AL: "High-affinity binding of interferon-gamma to a basement membrane complex (matrigel).", J CLIN INVEST, MARS 1991, VOL. 87, NO. 3, PAGE(S) 878-83, US, XP000568805
LORTAT-JACOB H ET AL: "Molecular organization of the interferon gamma-binding domain in heparan sulphate.", BIOCHEM J, SEP 1 1995, VOL. 310, NO. PT 2, PAGE(S) 497-505, ENGLAND, XP000568803
LORTAT-JACOB, H. ET AL: "Interferon - gamma, an anti-fibrogenic cytokine which binds to heparan sulfate", PATHOL., RES. PRACT., VOL. 190, NO. 9-10, PAGE(S) 920-2, 1994, XP000616388
LORTAT-JACOB, H. ET AL: "Interferon - gamma C-terminal function: new working hypothesis. Heparan sulfate and heparin, new targets for IFN-gamma, protect, relax the cytokine and regulate its activity", CELL. MOL. BIOL., VOL. 37, NO. 3, PAGE(S) 253-60, 1991, XP000616389
LIAN, REBECCA H. ET AL: "IFN-.gamma.-induced MHC class II gene expression is suppressed in endothelial cells by dextran sulfate", J. IMMUNOL., VOL. 157, NO. 2, PAGE(S) 864-873, 15 July 1996 (1996-07-15), XP002023901
LORTAT-JACOB, HUGUES ET AL: "Heparin decreases the blood clearance of interferon -. gamma. and increases its activity by limiting the processing of its carboxyl-terminal sequence", J. BIOL. CHEM., VOL. 271, NO. 27, PAGE(S) 16139-16143, 5 July 1996 (1996-07-05), XP002023902
RIX, D. A. ET AL: "Role of glycosaminoglycans (GAGs) in regulation of the immunogenicity of human vascular endothelial cells", CLIN. EXP. IMMUNOL., VOL. 104, NO. 1, PAGE(S) 60-5, April 1996 (1996-04-01), XP000616393
LORTAT-JACOB, HUGUES ET AL: "Non-receptor-mediated tissue localization of human interferon -. gamma.: role of heparan sulfate /heparin-like molecules", CYTOKINE, VOL. 8, NO. 7, PAGE(S) 557-566, July 1996 (1996-07-01), XP000616381
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