Title:
GAMMA-KETOACID DIPEPTIDES AS INHIBITORS OF CASPASE-3
Document Type and Number:
WIPO Patent Application WO2002020465
Kind Code:
A3
Abstract:
This invention encompasses the novel compounds of Formula I, which are useful in the treatment of caspase-3 mediated diseases.The invention also encompasses certain pharmaceutical compositions comprising compounds of Formula I as well as methods for treatment of caspase-3 mediated diseases.
Inventors:
HAN YONGXIN (CA)
GIROUX ANDRE (CA)
GRIMM ERICH L (CA)
ASPIOTIS RENEE (CA)
BLACK CAMERON (CA)
GIROUX ANDRE (CA)
GRIMM ERICH L (CA)
ASPIOTIS RENEE (CA)
BLACK CAMERON (CA)
Application Number:
PCT/CA2001/001272
Publication Date:
April 25, 2002
Filing Date:
September 06, 2001
Export Citation:
Assignee:
MERCK FROSST CANADA INC (CA)
HAN YONGXIN (CA)
GIROUX ANDRE (CA)
GRIMM ERICH L (CA)
ASPIOTIS RENEE (CA)
BLACK CAMERON (CA)
HAN YONGXIN (CA)
GIROUX ANDRE (CA)
GRIMM ERICH L (CA)
ASPIOTIS RENEE (CA)
BLACK CAMERON (CA)
International Classes:
C12N9/99; A61K38/55; A61P3/10; A61P9/00; A61P9/10; A61P17/14; A61P21/00; A61P25/00; A61P25/16; A61P25/28; A61P31/04; A61P31/18; A61P37/04; A61P43/00; C07C237/22; C07D213/63; C07D215/233; C07D217/24; C07D239/34; C07D241/44; C07D271/06; C07D307/86; C07D413/12; C07D495/04; C07K5/06; C07K5/062; C07K5/065; C07K5/078; C07D215/22
Domestic Patent References:
| WO1998016502A1 | 1998-04-23 |
Foreign References:
| GB2292149A | 1996-02-14 |
Other References:
NICHOLSON D W ET AL: "IDENTIFICATION AND INHIBITION OF THE ICE/CED-3 PROTEASE NECESSARY FOR MAMMALIAN APOPTOSIS", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 376, no. 6535, 6 July 1995 (1995-07-06), pages 37 - 43, XP000574812, ISSN: 0028-0836
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