Title:
GENES AND PROTEINS PREDICTIVE AND THERAPEUTIC FOR STROKE, HYPERTENSION, DIABETES AND OBESITY
Document Type and Number:
WIPO Patent Application WO2000018918
Kind Code:
A3
Abstract:
The present invention discloses genes whose expression is modulated in SHR-rats, which is an animal model for human metabolic X syndrome. Also disclosed are genes whose gene products are altered in SHR animals compared to control animals. The invention further discloses methods of diagnosing or treating conditions associated with metabolic X syndrome using these genes and gene products.
Inventors:
SHIMKETS RICHARD A (US)
Application Number:
PCT/US1999/022494
Publication Date:
November 30, 2000
Filing Date:
September 28, 1999
Export Citation:
Assignee:
CURAGEN CORP (US)
SHIMKETS RICHARD A (US)
SHIMKETS RICHARD A (US)
International Classes:
A01K67/027; A61K31/7088; A61K38/00; A61K39/395; A61K48/00; A61P3/04; A61P3/06; A61P9/10; A61P9/12; A61P43/00; C07K14/47; C07K14/58; C07K14/705; C07K16/18; C12N9/10; C12N9/88; C12N15/09; C12N15/12; C12Q1/25; C12Q1/52; C12Q1/68; G01N33/15; G01N33/50; (IPC1-7): C12N15/12; A01K67/027; A61K31/70; A61K38/17; A61K38/22; A61K38/45; A61K38/51; A61K39/395; A61P3/06; A61P3/10; A61P9/12; C07K14/47; C07K14/58; C07K14/705; C07K16/18; C07K16/26; C07K16/28; C07K16/40; C07K16/44; C12N9/10; C12N9/88; C12N15/52; C12N15/54; C12Q1/68; G01N33/50; G01N33/566
Other References:
YOU G. ET AL.: "Molecular characteristics of Na+-coupled glucose transporters in adult and embryonic rat kidney.", J. BIOL. CHEM., vol. 270, 1995, pages 29365 - 29371, XP002139557
WELLS R.G. ET AL.: "Cloning of a human kidney cDNA with similarity to the sodium-glucose cotransporter", AM. J. PHYSIOL., vol. 263, 1992, pages F459 - F465, XP000891650
PAJOR A.M. & WRIGHT E.M.: "Cloning and functional expression of a mammalian Na+/nucleoside cotransporter. A member of the SGLT2 family.", J. BIOL. CHEM., vol. 267, 1992, pages 3557 - 3560, XP002139558
KONG C.-T. ET AL.: "Cloning and expression of a mammalian Na+/amino acid cotransporter with sequence similarity to Na+/glucose cotransporter.", J. BIOL. CHEM., vol. 268, 1993, pages 1509 - 1512, XP002139559
AITMAN T.J. ET AL.: "Quantitative trait loci for cellular defects in glucose and fatty acid metabolism in hypertensive rats.", NATURE GENETICS, vol. 16, no. 2, June 1997 (1997-06-01), pages 197 - 201, XP000891667
LIGUORI M. ET AL.: "Insulino-resistenza", MINERVA ENDOCRINOLOGICA (ITALIAN), vol. 23, no. 2, June 1998 (1998-06-01), pages 37 - 52, XP000087447
WELLS R.G. ET AL.: "Cloning of a human kidney cDNA with similarity to the sodium-glucose cotransporter", AM. J. PHYSIOL., vol. 263, 1992, pages F459 - F465, XP000891650
PAJOR A.M. & WRIGHT E.M.: "Cloning and functional expression of a mammalian Na+/nucleoside cotransporter. A member of the SGLT2 family.", J. BIOL. CHEM., vol. 267, 1992, pages 3557 - 3560, XP002139558
KONG C.-T. ET AL.: "Cloning and expression of a mammalian Na+/amino acid cotransporter with sequence similarity to Na+/glucose cotransporter.", J. BIOL. CHEM., vol. 268, 1993, pages 1509 - 1512, XP002139559
AITMAN T.J. ET AL.: "Quantitative trait loci for cellular defects in glucose and fatty acid metabolism in hypertensive rats.", NATURE GENETICS, vol. 16, no. 2, June 1997 (1997-06-01), pages 197 - 201, XP000891667
LIGUORI M. ET AL.: "Insulino-resistenza", MINERVA ENDOCRINOLOGICA (ITALIAN), vol. 23, no. 2, June 1998 (1998-06-01), pages 37 - 52, XP000087447
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