Title:
alpha -SYNUCLEIN SUPER-MUTANTS ACCELERATE alpha -SYNUCLEIN AGGREGATION
Document Type and Number:
WIPO Patent Application WO2000018917
Kind Code:
A9
Abstract:
Parkinson's disease (PD) is a neurodegenerative disorder which is pathologically characterized by the presence of intracytoplasmic Lewy bodies, the major component of which are filaments consisting of alpha -synuclein. The present invention provides alpha -synuclein mutations which accelerate alpha -synuclein aggregation and can thus be utilized for transgenic animal production and generation of the first progressive PD model. Also provided is an in vitro aggregation assay which can be utilized to identify alpha -synuclein nucleation inhibitors for the treatment of PD.
Inventors:
BIERE ANJA LEONA
CITRON MARTIN
CITRON MARTIN
Application Number:
PCT/US1999/022302
Publication Date:
August 24, 2000
Filing Date:
September 27, 1999
Export Citation:
Assignee:
AMGEN INC (US)
International Classes:
A01K67/027; A61K45/00; A61P25/16; A61P43/00; C07K14/47; C12N15/09; C12N15/12; G01N33/15; G01N33/50; G01N33/566; G01N37/00; A61K38/00; (IPC1-7): C12N15/12; A01K67/027; A61K38/17; C07K14/47; G01N33/50
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