GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC CD27

Title:

GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC CD27

Document Type and Number:

WIPO Patent Application WO/2018/113774

Kind Code:

A1

Abstract:

Genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD27 are provided.

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Inventors:

SHEN YUELEI (CN)
BAI YANG (CN)
HUANG RUI (CN)
SHANG CHENGZHANG (CN)
GUO YANAN (CN)
ZHANG MEILING (CN)

Application Number:

PCT/CN2017/117984

Publication Date:

June 28, 2018

Filing Date:

December 22, 2017

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Assignee:

BEIJING BIOCYTOGEN CO LTD (CN)

International Classes:

C12N15/09; C12N15/12

Domestic Patent References:

WO2011130434A2	2011-10-20
WO2009100942A1	2009-08-20

Foreign References:

US20100173324A1	2010-07-08
US20120093805A1	2012-04-19

Other References:

HE, L.Z. ET AL.: "Agonist Anti-Human CD 27 Monoclonal Antibody Induces T Cell Activation and Tumor Immunity in Human CD 27-Transgenic Mice", THE JOURNAL OF IMMUNOLOGY, vol. 191, no. 8, 11 September 2013 (2013-09-11), pages 4174 - 4183, XP055496515, Retrieved from the Internet

Attorney, Agent or Firm:

BEIJING LINKTEC IP LAW AGENT(SPECIAL GENERAL PARTNERSHIP) (CN)

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