GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC CD47

Title:

GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC CD47

Document Type and Number:

WIPO Patent Application WO/2018/177440

Kind Code:

A1

Abstract:

Provided herein are genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD47, and methods of use thereof.

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Inventors:

SHEN YUELEI (CN)
BAI YANG (CN)
NI JIAN (CN)
HUANG RUI (CN)
SHANG CHENGZHANG (CN)
GUO YANAN (CN)

Application Number:

PCT/CN2018/081628

Publication Date:

October 04, 2018

Filing Date:

April 02, 2018

Export Citation:

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Assignee:

BEIJING BIOCYTOGEN CO LTD (CN)

International Classes:

A01K67/027; C07K14/705; G01N33/50

Domestic Patent References:

WO2016089692A1	2016-06-09
WO2007033221A2	2007-03-22
WO2016094679A1	2016-06-16

Foreign References:

CN104904661A

2015-09-16

Other References:

ZENG, G. M. ET AL.: "Generation and expression analysis of human (Homo sapiens) CD 47 transgenic Bama Miniature Pig (Sus scrofa", JOURNAL OF AGRICULTURAL BIOTECHNOLOGY, vol. 24, no. 8, 31 December 2016 (2016-12-31), pages 1251 - 1258
SHULTZ, L. D. ET AL.: "Humanized mice for immune system investigation: progress, promise and challenges", NATURE REVIEWS IMMUNOLOGY, vol. 12, no. 11, 12 October 2012 (2012-10-12), pages 786 - 798, XP055064740

Attorney, Agent or Firm:

BEIJING LINKTEC IP LAW AGENT (SPECIAL GENERAL PARTNERSHIP) (CN)

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