Title:
GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC SIRPα
Document Type and Number:
WIPO Patent Application WO/2018/177441
Kind Code:
A1
Abstract:
Provided herein are genetically modified non-human animals that express a human or chimeric (e.g., humanized) SIRPα, and methods of use thereof.
Inventors:
SHEN YUELEI (CN)
BAI YANG (CN)
ZHANG MEILING (CN)
HUANG RUI (CN)
SHANG CHENGZHANG (CN)
GUO YANAN (CN)
BAI YANG (CN)
ZHANG MEILING (CN)
HUANG RUI (CN)
SHANG CHENGZHANG (CN)
GUO YANAN (CN)
Application Number:
PCT/CN2018/081629
Publication Date:
October 04, 2018
Filing Date:
April 02, 2018
Export Citation:
Assignee:
BEIJING BIOCYTOGEN CO LTD (CN)
International Classes:
C12N15/90; A01K67/027; C07K14/705
Domestic Patent References:
| WO2016089692A1 | 2016-06-09 | |||
| WO2015042557A1 | 2015-03-26 | |||
| WO2012040207A2 | 2012-03-29 |
Foreign References:
| CN104039821A | 2014-09-10 |
Other References:
STROWIG, T. ET AL.: "Transgenic expression of human signal regulatory protein alpha in Rag2-/-yc-/-mice improves engraftment of human hematopoietic cells in humanized mice", PNAS., vol. 108, no. 32, 9 August 2011 (2011-08-09), pages 13218 - 13223, XP055533951
LEGRAND, N. ET AL.: "Functional CD 47/signal regulatory protein alpha (SIRPa) interaction is required for optimal human T- and natural killer- (NK) cell homeostasis in vivo", PNAS, vol. 108, no. 32, 9 August 2011 (2011-08-09), pages 13224 - 13229, XP002681727
INAGAKI, K. ET AL.: "SHPS-1 regulates integrin-mediated cytoskeletal reorganization and cell motility", THE EMBO JOURNAL, vol. 19, no. 24, 31 December 2000 (2000-12-31), pages 6721 - 6731, XP055165789
BARCLAY, A.N. ET AL.: "The Interaction Between Signal Regulatory Protein Alpha (SIRPa) and CD 47:Structure, Function, and Therapeutic Target", THE ANNUAL REVIEW OF IMMUNOLOGY, vol. 32, no. 1, 6 November 2013 (2013-11-06), pages 25 - 50, XP055166307
MURATA, Y.J. ET AL.: "Autoimmune animal models in the analysis of the CD 47-SIRPa signaling pathway", METHODS, vol. 65, no. 2, 31 December 2013 (2013-12-31), pages 254 - 259, XP055539809
LEGRAND, N. ET AL.: "Functional CD 47/signal regulatory protein alpha (SIRPa) interaction is required for optimal human T- and natural killer- (NK) cell homeostasis in vivo", PNAS, vol. 108, no. 32, 9 August 2011 (2011-08-09), pages 13224 - 13229, XP002681727
INAGAKI, K. ET AL.: "SHPS-1 regulates integrin-mediated cytoskeletal reorganization and cell motility", THE EMBO JOURNAL, vol. 19, no. 24, 31 December 2000 (2000-12-31), pages 6721 - 6731, XP055165789
BARCLAY, A.N. ET AL.: "The Interaction Between Signal Regulatory Protein Alpha (SIRPa) and CD 47:Structure, Function, and Therapeutic Target", THE ANNUAL REVIEW OF IMMUNOLOGY, vol. 32, no. 1, 6 November 2013 (2013-11-06), pages 25 - 50, XP055166307
MURATA, Y.J. ET AL.: "Autoimmune animal models in the analysis of the CD 47-SIRPa signaling pathway", METHODS, vol. 65, no. 2, 31 December 2013 (2013-12-31), pages 254 - 259, XP055539809
Attorney, Agent or Firm:
BEIJING LINKTEC IP LAW AGENT (SPECIAL GENERAL PARTNERSHIP) (CN)
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